Molecular characterization of AKAP149, a novel A kinase anchor protein with a KH domain

被引：72

作者：

Trendelenburg, G ^{[1
]}

Hummel, M ^{[1
]}

Riecken, EO ^{[1
]}

Hanski, C ^{[1
]}

机构：

[1] FREE UNIV BERLIN,KLINIKUM BENJAMIN FRANKLIN,DEPT PATHOL,D-12200 BERLIN,GERMANY

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 225卷 / 01期

关键词：

D O I：

10.1006/bbrc.1996.1172

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cytosolic cAMP activates in eukaryotic cells several isoforms of cAMP-dependent protein kinase (PKAs) involved in signal transduction. The effects of individual PKA isoforms are determined by their cellular localisation, specified through binding to distinct A Kinase Anchor Proteins (AKAPs). A new member of the AKAP family, a membrane-anchored 903 amino acid long protein, designated AKAP149, is characterized in the present work. It is a putative splicing variant of S-AKAP84 with the important new feature of a RNA-binding motif (KH domain). This domain together with the known characteristics of AKAPs suggests the involvement of AKAP149 in the phosphorylation-dependent regulation of RNA-processing. (C) 1996 Academic Press, Inc.

引用

页码：313 / 319

页数：7

共 22 条

[1]

ALTSCHUL SF, 1990, J MOL BIOL, V215, P403, DOI 10.1006/jmbi.1990.9999

[2] FMR1 PROTEIN - CONSERVED RNP FAMILY DOMAINS AND SELECTIVE RNA-BINDING [J].

ASHLEY, CT ;

WILKINSON, KD ;

REINES, D ;

WARREN, ST .

SCIENCE, 1993, 262 (5133) :563-566

[3] CONSERVED STRUCTURES AND DIVERSITY OF FUNCTIONS OF RNA-BINDING PROTEINS [J].

BURD, CG ;

DREYFUSS, G .

SCIENCE, 1994, 265 (5172) :615-621

[4]

HANSKI C, 1995, CANCER RES, V55, P928

[5] Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein [J].

Klauck, TM ;

Faux, MC ;

Labudda, K ;

Langeberg, LK ;

Jaken, S ;

Scott, JD .

SCIENCE, 1996, 271 (5255) :1589-1592

[6]

KOTERA Y, 1994, CANCER RES, V54, P2856

[7] THE SCANNING MODEL FOR TRANSLATION - AN UPDATE [J].

KOZAK, M .

JOURNAL OF CELL BIOLOGY, 1989, 108 (02) :229-241

[8] CHARACTERIZATION OF S-AKAP84, A NOVEL DEVELOPMENTALLY-REGULATED A-KINASE ANCHOR PROTEIN OF MALE GERM-CELLS [J].

LIN, RY ;

MOSS, SB ;

RUBIN, CS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (46) :27804-27811

[9] LOCALIZATION OF PROTEIN-KINASES BY ANCHORING PROTEINS - A THEME IN SIGNAL-TRANSDUCTION [J].

MOCHLYROSEN, D .

SCIENCE, 1995, 268 (5208) :247-251

[10] IMPROVED TOOLS FOR BIOLOGICAL SEQUENCE COMPARISON [J].

PEARSON, WR ;

LIPMAN, DJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (08) :2444-2448

← 1 2 3 →