Preparation of nano hydroxyapatite and β-cyclodextrin composite microspheres used in release of theophylline

被引：0

作者：

Guo, Yu Ping ^{[1
]}

Hu, Liang ^{[2
]}

Chen, Yu Qiong ^{[2
]}

Xing, Xiao Feng ^{[2
]}

Gao, Wei Min ^{[2
]}

机构：

[1] Jiangxi Sci & Technol Normal Univ, Sch Pharm, Nanchang, Peoples R China

[2] Jiangxi Sci & Technol Normal Univ, Jiangxi Key Lab Surface Engn, Nanchang, Peoples R China

来源：

COMPUTING, CONTROL, INFORMATION AND EDUCATION ENGINEERING | 2015年

关键词：

Nano hydroxyapatite; beta-Cyclodextrin; Microsphere; Theophylline;

D O I：

暂无

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

Nano hydroxyapatite (HA) and beta-cyclodextrin (beta-CD) polymer composite microspheres and their theophylline inclusion carriers were prepared. The morphology of nano HA was tailored by Gly and theophylline release from the composite microspheres was evaluated in vitro. Nano HA and the composite microspheres were characterized by TEM. The average diameter of products was 350 mu m and the drug loading and drug encapsulation efficiency were 1.79% and 89.50% respectively. The drug release profile could be described by first-order release equation and Korsmeyer-Peppas equation. The composite microspheres of nano HA and beta-CD polymer have a special absorption effect of drugs with special group, which might highlight the research for drug delivery system.

引用

页码：865 / 867

页数：3

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