Flavobacteriaceae Bacteremia in Children A Multicenter Study

被引:6
作者
Cooper, Shiri [1 ,2 ]
Levy, Itzhak [2 ,3 ]
Ben-Zvi, Haim [4 ]
Ashkenazi-Hoffnung, Liat [1 ,2 ,3 ]
Ben-Shimol, Shalom [5 ,6 ]
Shachor-Meyouhas, Yael [7 ,8 ]
Grisaru-Soen, Galia [9 ]
Kriger, Or [2 ,10 ]
Yahav, Dafna [2 ,11 ]
Scheuerman, Oded [1 ,2 ,3 ]
机构
[1] Schneider Childrens Med Ctr, Dept Pediat B, IL-4920235 Petah Tiqwa, Israel
[2] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel
[3] Beilinson Med Ctr, Dept Pediat, Infect Dis Unit, Schneider Childrens Med Ctr, Petah Tiqwa, Israel
[4] Beilinson Med Ctr, Microbiol Lab, Rabin Med Ctr, Petah Tiqwa, Israel
[5] Ben Gurion Univ Negev, Pediat Infect Dis Unit, Soroka Med Ctr, Beer Sheva, Israel
[6] Ben Gurion Univ Negev, Fac Hlth Sci, Beer Sheva, Israel
[7] Technion Israel Inst Technol, Pediat Infect Dis Unit, Rambam Med Ctr, Haifa, Israel
[8] Technion Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Haifa, Israel
[9] Tel Aviv Sourasky Med Ctr, Pediat Infect Dis Unit, Tel Aviv, Israel
[10] Sheba Med Ctr, Pediat Infect Dis Unit, Ramat Gan, Israel
[11] Beilinson Med Ctr, Rabin Med Ctr, Infect Dis Unit, Petah Tiqwa, Israel
关键词
Elizabethkingae meningosepticum; Chryseobacterium meningosepticum; Chryseobacterium indologenes; pediatrics; CHRYSEOBACTERIUM-INDOLOGENES; ANTIMICROBIAL SUSCEPTIBILITY; MENINGOSEPTICUM; INFECTIONS; NOV;
D O I
10.1097/INF.0000000000002449
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background: The Flavobacteriaceae family includes rare pathogens in children; Chryseobacterium indologenes and Elizabethkingia meningosepticum are the most common pathogenic species, with a wide range of clinical presentations and high mortality rate. Although rare, diagnosis is important due to inherent resistance to multiple antibiotics, especially those typically prescribed for empiric treatment of aerobic Gram-negative bacterial infections. Methods: A multicenter retrospective study conducted in 5 Israeli hospitals, describing Flavobacteriaceae bacteremia confirmed by positive blood culture from 1998 to 2018. Results: Thirteen cases were included; 9 isolates were C. indologenes. Bacteremia was nosocomial or healthcare-associated in all cases. Bacteremia was associated with young age (median, 1 year, range 24 days-17 years), with only 2 (15.4%) cases in neonates, Central line-associated bloodstream infection as a source (5/13, 38%) and malignancy (7/13, 54.8%). Thirty-day all-cause mortality was 23% (3/13). Ninety-one percent of isolates were susceptible to trimethoprim-sulfamethoxazole, 82% to piperacillin-tazobactam and 92% to ciprofloxacin. Conclusions: C. indologenes and E. meningosepticum are rare, nosocomial- or healthcare-associated pediatric bacteremia pathogens. Bacteremia was associated with young age, but in contrast to the literature, the majority of our cases were older than the neonatal age period. In addition, they were associated with central line-associated bloodstream infection and malignancy. The most adequate antibiotics according to resistance patterns were ciprofloxacin, trimethoprim-sulfamethoxazole and piperacillin-tazobactam.
引用
收藏
页码:1096 / 1099
页数:4
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