Detection of the HE4 protein in urine as a biomarker for ovarian neoplasms

被引：97

作者：

Hellstrom, Ingegerd ^{[1
]}

Heagerty, Patrick J. ^{[2
]}

Swisher, Elizabeth M. ^{[3
]}

Liu, Pu

Jaffar, Jade

Agnew, Kathy ^{[3
]}

Hellstrom, Karl Erik

机构：

[1] Univ Washington, Harborview Med Ctr, Dept Pathol, Seattle, WA 98104 USA

[2] Univ Washington, Dept Biostat, Seattle, WA 98104 USA

[3] Univ Washington, Dept Obstet Gynecol, Seattle, WA 98104 USA

来源：

CANCER LETTERS | 2010年 / 296卷 / 01期

关键词：

ELISA; Ovarian cancer diagnostics; Urine; HE4; MOLECULAR-CLONING; CDNA MICROARRAY; PELVIC MASS; EARLY-STAGE; CANCER; MESOTHELIN; CARCINOMA; EXPRESSION; SEQUENCE; ANTIGEN;

D O I：

10.1016/j.canlet.2010.03.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The HE4 protein is overexpressed in ovarian carcinomas and can be detected in serum by an ELISA with sensitivity similar to CA125 and higher specificity for malignant disease. We now demonstrate that HE4 can also be detected in the urine at a specificity level of 94.4%, including 13/15 (86.6%) with stage I/II and 57/64 (89.0%) with stage III/IV disease and including 90.5% of patients with serous ovarian carcinoma. Assaying serum and urine from the same patients showed similar sensitivity. Our data indicate that measuring HE4 in urine may aid diagnosis and the monitoring of response to therapy. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：43 / 48

页数：6

共 50 条

[1] Detection of the HE4 protein in urine as a biomarker for ovarian neoplasms: Clinical correlates
Liao, John B.
Yip, Yuen Yee
Swisher, Elizabeth M.
Agnew, Kathy
Hellstrom, Karl Erik
Hellstrom, Ingegerd
GYNECOLOGIC ONCOLOGY, 2015, 137 (03) : 430 - 435
[2] HE4 protein and SMRP: Potential novel biomarkers in ovarian cancer detection
Fritz-Rdzanek, Anna
Grzybowski, Wojciech
Beta, Jaroslaw
Durczynski, Andrzej
Jakimiuk, Artur
ONCOLOGY LETTERS, 2012, 4 (03) : 385 - 389
[3] HE4: really a novel biomarker for ovarian cancer?
Yucel, E.
Ilter, E.
Aksungar, F. B.
Celik, A.
Peker, B. H.
Serifsoy, E.
Bozkurt, S.
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, 2017, 38 (01) : 59 - 64
[4] Urine CA125 and HE4 for the Detection of Ovarian Cancer in Symptomatic Women
Barr, Chloe E.
Njoku, Kelechi
Owens, Gemma L.
Crosbie, Emma J.
CANCERS, 2023, 15 (04)
[5] HE4 as an Early Detection Biomarker of Epithelial Ovarian Cancer Investigations in Prediagnostic Specimens From the Janus Serumbank
Gislefoss, Randi Elin
Langseth, Hilde
Bolstad, Nils
Nustad, Kjell
Morkrid, Lars
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2015, 25 (09) : 1608 - 1615
[6] HE4: a new potential early biomarker for the recurrence of ovarian cancer
Anastasi, Emanuela
Marchei, Giulia Giovanna
Viggiani, Valentina
Gennarini, Giuseppina
Frati, Luigi
Reale, Maria Gabriella
TUMOR BIOLOGY, 2010, 31 (02) : 113 - 119
[7] HE4 and Mesothelin: Novel Biomarkers of Ovarian Carcinoma in Patients with Pelvic Masses
Abdel-Azeez, Hala A.
Labib, Hany A.
Sharaf, Samar M.
Refaie, Ashraf N.
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2010, 11 (01) : 111 - 116
[8] Human epididymal protein 4 (HE4) is a novel biomarker and a promising prognostic factor in ovarian cancer patients
Chudecka-Glaz, A.
Rzepka-Gorska, I.
Wojciechowska, I.
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, 2012, 33 (04) : 382 - 390
[9] Human Epididymis Protein 4 (HE4) as a Serum Tumor Biomarker in Patients With Ovarian Carcinoma
Chang, Xiaohong
Ye, Xue
Dong, Li
Cheng, Hongyan
Cheng, Yexia
Zhu, Lirong
Liao, Qinping
Zhao, Yang
Tian, Li
Fu, Tianyun
Chen, Jun
Cui, Heng
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2011, 21 (05) : 852 - 858
[10] Serum levels of the ovarian cancer biomarker HE4 are decreased in pregnancy and increase with age
Moore, Richard G.
Miller, Michael Craig
Eklund, Elizabeth E.
Lu, Karen H.
Bast, Robert C., Jr.
Lambert-Messerlian, Geralyn
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2012, 206 (04) : 349.e1 - 349.e7

← 1 2 3 4 5 →