Detection of the HE4 protein in urine as a biomarker for ovarian neoplasms

被引：97

作者：

Hellstrom, Ingegerd ^{[1
]}

Heagerty, Patrick J. ^{[2
]}

Swisher, Elizabeth M. ^{[3
]}

Liu, Pu

Jaffar, Jade

Agnew, Kathy ^{[3
]}

Hellstrom, Karl Erik

机构：

[1] Univ Washington, Harborview Med Ctr, Dept Pathol, Seattle, WA 98104 USA

[2] Univ Washington, Dept Biostat, Seattle, WA 98104 USA

[3] Univ Washington, Dept Obstet Gynecol, Seattle, WA 98104 USA

来源：

CANCER LETTERS | 2010年 / 296卷 / 01期

关键词：

ELISA; Ovarian cancer diagnostics; Urine; HE4; MOLECULAR-CLONING; CDNA MICROARRAY; PELVIC MASS; EARLY-STAGE; CANCER; MESOTHELIN; CARCINOMA; EXPRESSION; SEQUENCE; ANTIGEN;

D O I：

10.1016/j.canlet.2010.03.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The HE4 protein is overexpressed in ovarian carcinomas and can be detected in serum by an ELISA with sensitivity similar to CA125 and higher specificity for malignant disease. We now demonstrate that HE4 can also be detected in the urine at a specificity level of 94.4%, including 13/15 (86.6%) with stage I/II and 57/64 (89.0%) with stage III/IV disease and including 90.5% of patients with serous ovarian carcinoma. Assaying serum and urine from the same patients showed similar sensitivity. Our data indicate that measuring HE4 in urine may aid diagnosis and the monitoring of response to therapy. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：43 / 48

页数：6

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