A new dosage regimen for topical application of ciprofloxacin in the management of chronic suppurative otitis media

The clinical and bacteriologic efficacy of topically applied ciprofloxacin was studied in 60 patients with chronic suppurative otitis media, Two hundred fifty and 125 mu g/ml concentrations of ciprofloxacin solutions were given to two groups of patients. The duration of therapy was determined according to the clinical cure at follow-up. More than 21 days of therapy was not needed in any patient, The clinical cure rate with 250 mu g/ml ciprofloxacin was 78.1% at 14 days and with 125 mu g/ml it was 83.3%, However, a 100% clinical cure rate and complete bacteriologic eradication was obtained in 21 days in both groups, In each group only one patient had otomycosis by the fourteenth day of therapy, although ear discharge had ceased, It was concluded that 125 mu g/ml ciprofloxacin could be applied as successfully as 250 mu g/ml, and the duration of therapy had to be at least 14 days. This new dosage regimen can be adopted as an optimal dosage for ototopical application of ciprofloxacin in chronic suppurative otitis media. it will also obviously decrease the expense of therapy.