In vitro scolicidal activity of Thymus capitatus Hoff. et Link. essential oil on Echinococcus granulosus protoscoleces

被引：6

作者：

Hizem, Amani ^{[1
]}

M'rad, Selim ^{[1
]}

Oudni-M'rad, Myriam ^{[1
]}

Mezhoud, Habib ^{[1
]}

Ben Jannet, Hichem ^{[2
]}

Flamini, Guido ^{[3
,4
]}

Ghedira, Kamel ^{[5
]}

Babba, Hamouda ^{[1
,6
]}

机构：

[1] Univ Monastir, Fac Pharm Monastir, LP3M Lab Parasitol Mycol Med & Mol, LR 12ES08, Monastir, Tunisia

[2] Univ Monastir, Fac Sci Monastir, Equipe Chim Med & Prod Nat, Lab Chim Heterocycl Prod Nat & React, Monastir, Tunisia

[3] Univ Pisa, Dipartimento Farm, Pisa, Italy

[4] Univ Pisa, Ctr Interdipartimentale Ric Nutraceut & Alimentaz, Pisa, Italy

[5] Univ Monastir, Unite Subst Nat Bioact & Biotechnol, Fac Pharm Monastir, UR17 ES49, Monastir, Tunisia

[6] Ctr Matern EPS F Bourguiba, Lab B, Monastir, Tunisia

来源：

JOURNAL OF ESSENTIAL OIL RESEARCH | 2020年 / 32卷 / 02期

关键词：

Cystic echinococcosis; Echinococcus granulosus; essential oil; Thymus capitatus; scolicidal agents; CHEMICAL-COMPOSITION; HYPERTONIC SALINE; HYDATID CYSTS; ANTIOXIDANT; L; ANTIBACTERIAL; ALBENDAZOLE; MECHANISMS; CARVACROL; EFFICACY;

D O I：

10.1080/10412905.2019.1711212

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Cystic echinococcosis remains a serious public health problem worldwide. Surgery is considered as the first option of treatment. Various investigations were carried out to find a convenient scolicidal agent for reducing the risk of post-surgical recurrence of the disease but most of them are associated with adverse side effects. The present study aimed to evaluate the in vitro scolicidal activity of Thymus capitatus Hoff. et Link. essential oil against Echinococcus granulosus protoscoleces. Three concentrations of essential oil (1, 2 and 3 mg/mL) were tested for 1 to 10 min on E. granulosus protosoleces and their viability was assessed by eosin staining test. The essential oil concentrated at 2 and 3 mg/mL killed 100% protoscoleces after 5 and 1 min, respectively. Furthermore, GC/MS and GC-FID analyzes indicated that carvacrol (82.4%) was the major component of the essential oil. The current investigation showed the potent scolicidal effect of T. capitatus essential oil in vitro.

引用

页码：178 / 185

页数：8

共 46 条

[11] GAS-CHROMATOGRAPHIC RETENTION INDEXES OF MONOTERPENES AND SESQUITERPENES ON METHYL SILICONE AND CARBOWAX 20M PHASES [J].