Mesenchymal stem cells and hematopoietic stem cell transplantation

被引：63

作者：

Fibbe, WE ^{[1
]}

Noort, WA ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Hematol, Lab Expt Hematol, NL-2333 AA Leiden, Netherlands

来源：

HEMATOPOIETIC STEM CELLS 2002: GENETICS AND FUNCTION | 2003年 / 996卷

关键词：

mesenchymal stem cells; stromal cells; stem cell transplantation; hematopoietic stem cells; engraftment;

D O I：

10.1111/j.1749-6632.2003.tb03252.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Techniques have recently beome available to isolate and grow mesenchymal progenitors and to manipulate their growth under defined in vitro culture conditions. As a result mesenchymal stem cells can be rapidly expanded to numbers that are required for clinical application. This has allowed the clinical testing of culture-expanded MSCs in the context of hematopoietic stem cell transplantation. In this paper we discuss the role of MSCs in hematopoietic engraftment after transplantation.

引用

页码：235 / 244

页数：10

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