Preparation of 2-Substituted 3-Methoxycarbonyl-4-methoxyfurans that Allow Access to Highly Functionalized Naphthalenes via Regioselective Cycloaddition with Alkoxybenzyne

被引：6

作者：

Sato, Shogo ^{[1
]}

Kawada, Takuma ^{[1
]}

Takikawa, Hiroshi ^{[1
]}

Suzuki, Keisuke ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Chem, Meguro Ku, 2-12-1 O Okayama, Tokyo 1528551, Japan

来源：

SYNLETT | 2017年 / 28卷 / 14期

基金：

日本学术振兴会;

关键词：

natural products; cycloaddition; furans; benzyne; KETENE SILYL ACETAL; C-ARYL GLYCOSIDES; ALPHA-ALKOXYBENZYNE; FORMAL SYNTHESIS; BENZYNE; DERIVATIVES; DEOXYGENATION; EFFICIENT; BENZOCYCLOBUTENONES; LACTONAMYCIN;

D O I：

10.1055/s-0036-1590825

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile synthetic method of 2-substituted 3-methoxycarbonyl-4-methoxyfurans has been developed, allowing construction of highly functionalized naphthalene derivatives via (1) regioselective benzyne [4+2] cycloaddition with -alkoxybenzyne and (2) reductive aromatization.

引用

页码：1719 / 1723

页数：5

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