Ring-opening cryo-polymerization of N-carboxy-α-amino acid anhydride of γ-benzyl L-Glutamate

被引：6

作者：

Li, Xi-Chuan ^{[1
]}

Hu, Chuan-Shan ^{[1
]}

Li, Hui-Juan ^{[1
]}

Li, Peng-Yun ^{[1
]}

Haleem, Abdul ^{[1
]}

He, Wei-Dong ^{[1
]}

机构：

[1] Univ Sci & Technol China, Dept Polymer Sci & Engn, CAS Key Lab Soft Matter Chem, Hefei 230026, Anhui, Peoples R China

来源：

POLYMER | 2018年 / 151卷

基金：

中国国家自然科学基金;

关键词：

Living polymerization; Ring-opening polymerization; Solid-state polymerization; Peptides; Kinetics; LIVING POLYMERIZATION; CARBOXYANHYDRIDES; NCA; POLYPEPTIDES; TEMPERATURE; HYDROGELS; PROTEINS;

D O I：

10.1016/j.polymer.2018.07.053

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Ring-opening polymerization (ROP) of N-carboxy-alpha-amino acid anhydride (NCA) of gamma-benzyl I.-glutamate (BLG) was investigated under frozen condition for the first time. This cryo-ROP was performed in DMSO or 1,4-dioxane below the freezing point of polymerization mixture. The kinetics was monitored with proton nuclear magnetic resonance spectroscopy and gel permeation chromatography, disclosing the well control over molecular weight, living polymerization features and considerable polymerization rate. Compared with the polymerization proceeded at 30 degrees C, which showed weak linearity regarding the reaction kinetics and relatively broad distribution of molecular weight, the cryo-ROP exhibited excellent first-order kinetics as well as narrow molecular distribution. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：1 / 5

页数：5

共 37 条

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