Recurrent involvement of heterochromatic regions in multiple myeloma-A multicolor FISH study

被引：9

作者：

Lange, Kathrin ^{[1
]}

Gadzicki, Dorothea ^{[1
]}

Schlegelberger, Brigitte ^{[1
]}

Goehring, Gudrun ^{[1
]}

机构：

[1] Hannover Med Sch, Inst Cell & Mol Pathol, D-30625 Hannover, Germany

来源：

LEUKEMIA RESEARCH | 2010年 / 34卷 / 08期

关键词：

Multiple myeloma; Chromosome aberration; Multicolor FISH; Isochromosomes; Heterochromatic regions; Genetic instability; IN-SITU HYBRIDIZATION; CYTOGENETIC ABERRATIONS; TRANSLOCATIONS; LEUKEMIA;

D O I：

10.1016/j.leukres.2009.10.027

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chromosome aberrations are important prognostic markers in multiple myeloma (MM), but their identification may be hampered by complexity of the karyotypes. Using multicolor fluorescence in situ hybridization (mFISH), we found cryptic aberrations in 7 of 10 patients with a complex karyotype. Moreover, in addition to typical aberrations involving 1q, 13q, 14q and 17p and structural aberrations in chromosomes 1, 6, 9 and 19, (iso)dicentric chromosomes and whole-arm translocations were detected. These chromosome aberrations were generated by breaks in heterochromatic regions indicating an increased breakage of these regions, which may predispose to the generation of chromosome aberrations in multiple myeloma. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1002 / 1006

页数：5

共 22 条

[11]

MITELMAN F, 1995, ISCN GUIDELINES CA S

[12]

Mitelman FJ., 2009, Mitelman Database of Chromosome Aberrations in Cancer

[13] Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability [J].

Peters, AHFM ;

O'Carroll, D ;

Scherthan, H ;

Mechtler, K ;

Sauer, S ;

Schöfer, C ;

Weipoltshammer, K ;

Pagani, M ;

Lachner, M ;

Kohlmaier, A ;

Opravil, S ;

Doyle, M ;

Sibilia, M ;

Jenuwein, T .

CELL, 2001, 107 (03) :323-337

[14] Multiple myeloma [J].

Raab, Marc S. ;

Podar, Klaus ;

Breitkreutz, Iris ;

Richardson, Paul G. ;

Anderson, Kenneth C. .

LANCET, 2009, 374 (9686) :324-339

[15] Genomic instability in multiple myeloma: Evidence for jumping segmental duplications of chromosome arm Iq [J].

Sawyer, JR ;

Tricot, G ;

Lukacs, JL ;

Binz, RL ;

Tian, E ;

Barlogie, B ;

Shaughnessy, J .

GENES CHROMOSOMES & CANCER, 2005, 42 (01) :95-106

[16] Prognostic impact of cytogenetic aberrations in patients with multiple myeloma or monoclonal gammopathy of unknown significance [J].

Schilling, G ;

Dierlamm, J ;

Hossfeld, DK .

HEMATOLOGICAL ONCOLOGY, 2005, 23 (3-4) :102-107

[17]

Schlegelberger B., 1999, Diagnostic Cytogenetics, P151, DOI [10.1007/978-3-642-59918-7_9, DOI 10.1007/978-3-642-59918-7_9]

[18] A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin [J].

Schotta, G ;

Lachner, M ;

Sarma, K ;

Ebert, A ;

Sengupta, R ;

Reuter, G ;

Reinberg, D ;

Jenuwein, T .

GENES & DEVELOPMENT, 2004, 18 (11) :1251-1262

[19] Prognostic and therapeutic significance of myeloma genetics and gene expression profiling [J].

Stewart, AK ;

Fonseca, R .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (26) :6339-6344

[20] Standardised fluorescence in situ hybridisation in cytological and histological specimens [J].

Wilkens, L ;

Gerr, H ;

Gadzicki, D ;

Kreipe, H ;

Schlegelberger, B .

VIRCHOWS ARCHIV, 2005, 447 (03) :586-592

← 1 2 3 →