Recurrent involvement of heterochromatic regions in multiple myeloma-A multicolor FISH study

被引：9
作者：
Lange, Kathrin [1 ]
Gadzicki, Dorothea [1 ]
Schlegelberger, Brigitte [1 ]
Goehring, Gudrun [1 ]
机构：
[1] Hannover Med Sch, Inst Cell & Mol Pathol, D-30625 Hannover, Germany
来源：
LEUKEMIA RESEARCH | 2010年 / 34卷 / 08期
关键词：
Multiple myeloma; Chromosome aberration; Multicolor FISH; Isochromosomes; Heterochromatic regions; Genetic instability; IN-SITU HYBRIDIZATION; CYTOGENETIC ABERRATIONS; TRANSLOCATIONS; LEUKEMIA;
D O I：
10.1016/j.leukres.2009.10.027
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Chromosome aberrations are important prognostic markers in multiple myeloma (MM), but their identification may be hampered by complexity of the karyotypes. Using multicolor fluorescence in situ hybridization (mFISH), we found cryptic aberrations in 7 of 10 patients with a complex karyotype. Moreover, in addition to typical aberrations involving 1q, 13q, 14q and 17p and structural aberrations in chromosomes 1, 6, 9 and 19, (iso)dicentric chromosomes and whole-arm translocations were detected. These chromosome aberrations were generated by breaks in heterochromatic regions indicating an increased breakage of these regions, which may predispose to the generation of chromosome aberrations in multiple myeloma. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1002 / 1006
页数：5
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