Deoxycholic acid derived monophosphites as chiral ligands in the asymmetric Suzuki-Miyaura cross-coupling

被引：15

作者：

Jumde, Varsha R. ^{[1
]}

Iuliano, Anna ^{[1
]}

机构：

[1] Univ Pisa, Dipartimento Chim & Chim Ind, I-56126 Pisa, Italy

来源：

TETRAHEDRON-ASYMMETRY | 2011年 / 22卷 / 24期

关键词：

STEREOCHEMICAL CHARACTERIZATION; TUNABLE COORDINATION; CONJUGATE ADDITION; ARYLBORONIC ACIDS; TROPOS LIGANDS; COMPLEXES; BIPHENYLPHOSPHITES; DIETHYLZINC; INDUCTION; PHOSPHITE;

D O I：

10.1016/j.tetasy.2011.12.006

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Biaryl phosphites derived from deoxycholic acid were used as chiral ligands in the asymmetric Suzuki-Miyaura cross-coupling of arylboronic acids with aryl bromides. Amongst the different reaction parameters, the role of the base emerged as being crucial for the outcome of the reaction: the choice of base, and its amount, allowed enantiomerically enriched biaryl derivatives to be obtained at 1% catalyst loading and with an L:Pd ratio of 1:1. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：2151 / 2155

页数：5

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