Novel cytotoxic seco-abietane rearranged diterpenoids from Salvia prionitis

被引：36

作者：

Chang, J ^{[1
]}

Xu, J ^{[1
]}

Li, M ^{[1
]}

Zhao, M ^{[1
]}

Ding, J ^{[1
]}

Zhang, JS ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

来源：

PLANTA MEDICA | 2005年 / 71卷 / 09期

关键词：

Salvia prionitis; Labiatae; diterpenoid; prionoids A-F; cytotoxic activity;

D O I：

10.1055/s-2005-871279

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Six novel 4,5-seco-rearranged abietane diterpenoids, including one tetracyclic diterpenoid, prionoid A (1), two tricyclic diterpenoids, prionoids B (2) and C (3), and three dicyclic diterpenoids, prionoids D (4), E (5), and F (6), were isolated from the roots of Salvia prionitis Hance (Labiatae). Their structures were elucidated using spectroscopic analysis. The structure of 1 was further confirmed by a single-crystal X-ray diffraction determination. Moreover, it was found that 4 (IC50 = 0.41 mu M) and 5 (IC50 = 0.72 mu M) showed significant cytotoxic activity against P-388 and A-549 cell lines, respectively.

引用

页码：861 / 866

页数：6

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