Two German Birth Cohorts: GINIplus and LISAplus

被引：27

作者：

Heinrich, J. ^{[1
]}

Brueske, I. ^{[1
]}

Schnappinger, M. ^{[1
]}

Standl, M. ^{[1
]}

Flexeder, C. ^{[1
]}

Thiering, E. ^{[1
]}

Tischer, C. ^{[1
]}

Tiesler, C. M. T. ^{[1
,2
]}

Kohlboeck, G. ^{[1
]}

Wenig, C. M. ^{[3
,4
,5
]}

Bauer, C. P. ^{[6
]}

Schaaf, B.

von Berg, A.

Berdel, D.

Kraemer, U. ^{[7
]}

Cramer, C. ^{[7
]}

Lehmann, I. ^{[8
]}

Herbarth, O. ^{[9
]}

Behrendt, H. ^{[10
]}

Ring, J. ^{[10
]}

Kuehnisch, J. ^{[11
]}

Koletzko, S. ^{[2
]}

机构：

[1] Helmholtz Zentrum Munchen, Deutsch Forschungszentrum Gesundheit & Umwelt, Inst Epidemiol 1, D-85764 Neuherberg, Germany

[2] Univ Munich, Dr von Haunersches Kinderspital, Munich, Germany

[3] Univ Munich, Inst Gesundheitsokon & Management Gesundheitswese, Munich, Germany

[4] Univ Munich, Munchner Zentrum Gesundheitswissensch, Munich, Germany

[5] Deutsch Forschungszentrum Gesundheit & Umwelt, Inst Gesundheitsokon & Management Gesundheitswese, Helmholtz Zentrum Munchen, Neuherberg, Germany

[6] Tech Univ Munich, Kinderklin, Munich, Germany

[7] Leibniz Inst Umweltmed Forsch IUF, Dusseldorf, Germany

[8] UFZ Helmholtz Zentrum, Dept Exposit Forsch & Epidemiol, Leipzig, Germany

[9] Univ Leipzig, Fak Med, Inst Umweltmed & Hyg, Leipzig, Germany

[10] Tech Univ Munich, Zentrum Allergie & Umwelt ZAUM, Munich, Germany

[11] Univ Munich, Poliklin Zahnerhaltung & Parodontol, Munich, Germany

来源：

BUNDESGESUNDHEITSBLATT-GESUNDHEITSFORSCHUNG-GESUNDHEITSSCHUTZ | 2012年 / 55卷 / 6-7期

关键词：

Birth cohort; Overweight; Allergy; Mental health; Environmental factors; SOLID FOOD INTRODUCTION; CORD BLOOD; ALLERGIC SENSITIZATION; INSULIN-RESISTANCE; ATOPIC-DERMATITIS; INFANT FORMULAS; AIR-POLLUTION; MENTAL-HEALTH; ECZEMA; AGE;

D O I：

10.1007/s00103-012-1485-4

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Numerous chronic diseases in childhood and adulthood have their origins in perinatal life and are potentially influenced by trans-generational epigenetic processes. Therefore, prospective birth cohorts can substantially contribute to our knowledge about the etiology of diseases including modifiable risk factors. The two population-based German birth cohorts GINIplus and LISAplus aim to describe the natural course of chronic diseases and intermediate phenotypes in childhood and its determinants, and to identify potential genetic effect modifications. In the mid-1990s, 5,991 (GINIplus) and 3,097 (LISAplus) healthy, term newborns were recruited for long-term follow-up in four regions of Germany. The follow-up rate for the first 10 years was about 55%. We analyzed the growth and development of overweight, infections and allergic diseases, mental and oral health, metabolic and inflammatory parameters and the role of potential risk factors including genetics. The results of these two birth cohorts substantially contribute to the current knowledge about the natural course of these health parameters. These data were included in many international projects and consortia for purposes of international comparisons of prevalence and consistency of findings, and to increase the power of the analyses.

引用

页码：864 / 874

页数：11

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