Synthesis and hydrolysis studies of novel glyco-functionalized platinum complexes

被引：15

作者：

Moeker, Janina ^{[1
]}

Thiem, Joachim ^{[1
]}

机构：

[1] Univ Hamburg, Fac Sci, Dept Chem, D-20146 Hamburg, Germany

来源：

CARBOHYDRATE RESEARCH | 2012年 / 348卷

关键词：

Antitumour agents; Platinum complexes; Sugar ethers; Sugar-functionalized complexes; ANTITUMOR-ACTIVITY; CARBOPLATIN; CISPLATIN; OXALIPLATIN;

D O I：

10.1016/j.carres.2011.08.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cisplatin and some of its derivatives are among the most active cytostatics for cancer treatment. Unfortunately, application of platinum complexes always indicates side effects, and frequently primary or developed resistance of tumour cells appear. Therefore, development of novel analogues especially with natural ligands is expedited. Glyco-functionalized ligands were obtained via ether synthesis with to-halo ethers, Finkelstein reaction, with further treatment with malonate and final deprotection followed by preparation of the disodium salts. Subsequent complexation led to novel platinum derivatives, the stabilities of which in aqueous solution media were studied. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：14 / 26

页数：13

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