The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition

被引：90

作者：

Sacco, Michael Dominic ^{[1
]}

Hu, Yanmei ^{[2
]}

Gongora, Maura Verenice ^{[1
]}

Meilleur, Flora ^{[3
,4
]}

Kemp, Michael Trent ^{[1
]}

Zhang, Xiujun ^{[1
]}

Wang, Jun ^{[2
]}

Chen, Yu ^{[1
]}

机构：

[1] Univ S Florida, Morsani Coll Med, Dept Mol Med, Tampa, FL 33620 USA

[2] Rutgers State Univ, Ernest Mario Sch Pharm, Dept Med Chem, Piscataway, NJ 08854 USA

[3] North Carolina State Univ, Dept Mol & Struct Biochem, Raleigh, NC 27695 USA

[4] Oak Ridge Natl Lab, Neutron Scattering Div, Oak Ridge, TN USA

来源：

CELL RESEARCH | 2022年 / 32卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/s41422-022-00640-y

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

引用

页码：498 / 500

页数：3

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