Calcium channel blockers and Alzheimer's disease

被引：19
作者：
Tan, Yi [1 ]
Deng, Yulin [1 ]
Qing, Hong [1 ]
机构：
[1] Beijing Inst Technol, Sch Life Sci, Beijing 100081, Peoples R China
来源：
NEURAL REGENERATION RESEARCH | 2012年 / 7卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Alzheimer's disease; calcium channel; calcium homeostasis; Alzheimer's disease pathogenesis; beta-amyloid; calcium channel blocker; CASPASE-CLEAVED TAU; MITOCHONDRIAL FISSION; AMYLOID-BETA; PARKINSONS-DISEASE; DYNAMICS; NEURONS; EXPRESSION; FUSION; PROTEINS; PINK1;
D O I：
10.3969/j.issn.1673-5374.2012.02.010
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Alzheimer's disease is characterized by two pathological hallmarks: amyloid plaques and neurofibrillary tangles. In addition, calcium homeostasis is disrupted in the course of human aging. Recent research shows that dense plagues can cause functional alteration of calcium signals in mice with Alzheimer's disease. Calcium channel blockers are effective therapeutics for treating Alzheimer's disease. This review provides an overview of the current research of calcium channel blockers involved in Alzheimer's disease therapy.
引用
收藏
页码：137 / 140
页数：4
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