Photosensitizer-conjugated Cu-In-S heterostructured nanorods for cancer targeted photothermal/photodynamic synergistic therapy

被引：13

作者：

Chen, Si-Han ^{[1
]}

Huang, Wan-Wen ^{[1
]}

Dehvari, Khalilalrahman ^{[1
]}

Ling, Yong-Chien ^{[2
]}

Ghule, Anil V. ^{[3
]}

Tsai, Shen-Long ^{[1
]}

Chang, Jia-Yaw ^{[1
,4
]}

机构：

[1] Natl Taiwan Univ Sci & Technol, Dept Chem Engn, 43,Sect 4,Keelung Rd, Taipei 10607, Taiwan

[2] Natl Tsing Hua Univ, Dept Chem, Hsinchu 30013, Taiwan

[3] Shivaji Univ, Dept Chem, Kolhapur 416004, Maharashtra, India

[4] Natl Taiwan Univ Sci & Technol, Taiwan Bldg Technol Ctr, Taipei 10607, Taiwan

来源：

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2019年 / 97卷

关键词：

Nanohybrids; Cu-in-S; Hyaluronic acid; Photothermal therapy; Photodynamic therapy; INFRARED PHOTOTHERMAL THERAPY; QUANTUM DOTS; THERANOSTIC AGENT; ABLATION; NANOPARTICLES; GRAPHENE; CUINS2; NANOCRYSTALS; EFFICIENCY; DELIVERY;

D O I：

10.1016/j.msec.2018.12.107

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Photo-activated therapy is a non-invasive and promising medical technology for the treatment of cancers. Herein, we present Ce6-HA-CIS phototherapeutic nanohybrids composed of Cu-In-S (CIS) heterostructured nanorod (HS-rod), chlorin e6 (Ce6), and hyaluronic acid (HA) for the use in targeted photodynamic/photothermal therapy (PDT/PTT). In the Ce6-HA-CIS nanohybrids, the CIS HS-rod was investigated as a PIT agent to convert light into thermal energy, with Ce6 acting as a PDT agent to generate singlet oxygen (O-1(2)). HA encapsulated the surface of the CIS HS-rod and aided the hydrophobic CIS HS-rod in achieving aqueous solubility. HA also acts as a tumor-specific targeting vector of cancer cells bearing the cluster determinant 44 receptor. Under light irradiation, the fabricated Ce6-HA-CIS nanohybrids exhibited high photothermal conversion efficiency, good photo stability, and satisfactory photodynamic activity. In vitro and in vivo experiments demonstrated that Ce6-HA-CIS showed low cytotoxicity and synergistic photodynamic and photothermal cancer cell killing effects as compared to PTT or PDT agents alone. Therefore, these phototherapeutic nanohybrids may enhance cancer therapy in future clinical applications.

引用

页码：793 / 802

页数：10

共 37 条

[1] Optical functions and electronic structure of CuInSe2, CuGaSe2, CuInS2, and CuGaS2 -: art. no. 075203 [J].

Alonso, MI ;

Wakita, K ;

Pascual, J ;

Garriga, M ;

Yamamoto, N .

PHYSICAL REVIEW B, 2001, 63 (07)

[2] Highly Efficient NIR-II Photothermal Conversion Based on an Organic Conjugated Polymer [J].

Cao, Yuanyuan ;

Dou, Jin-Hu ;

Zhao, Ning-jiu ;

Zhang, Shiming ;

Zheng, Yu-Qing ;

Zhang, Jian-Ping ;

Wang, Jie-Yu ;

Pei, Jian ;

Wang, Yapei .

CHEMISTRY OF MATERIALS, 2017, 29 (02) :718-725

[3] Development of Nonstoichiometric CuInS2 as a Light-Harvesting Photoanode and Catalytic Photocathode in a Sensitized Solar Cell [J].

Chang, Jia-Yaw ;

Chang, Shueh Chien ;

Tzing, Shin-Hwa ;

Li, Chen-Hei .

ACS APPLIED MATERIALS & INTERFACES, 2014, 6 (24) :22272-22281

[4] Ultrahigh 19F Loaded Cu1.75S Nanoprobes for Simultaneous 19F Magnetic Resonance Imaging and Photothermal Therapy [J].

Chen, Hongli ;

Song, Manli ;

Tang, Juan ;

Hu, Gaofei ;

Xu, Suying ;

Guo, Zhide ;

Li, Nannan ;

Cui, Jiabin ;

Zhang, Xianzhong ;

Chen, Xiaoyuan ;

Wang, Leyu .

ACS NANO, 2016, 10 (01) :1355-1362

[5] Activatable Multifunctional Persistent Luminescence Nanoparticle/Copper Sulfide Nanoprobe for in Vivo Luminescence Imaging Guided Photothermal Therapy [J].

Chen, Li-Jian ;

Sun, Shao-Kai ;

Wang, Yong ;

Yang, Cheng-Xiong ;

Wu, Shu-Qi ;

Yan, Xiu-Ping .

ACS APPLIED MATERIALS & INTERFACES, 2016, 8 (48) :32667-32674

[6]

Cheng L, 2012, ACS NANO, V6, P5605, DOI [10.1021/nn301539m, 10.1021/nn304719q]

[7] Superparamagnetic Iron Oxide Nanorod Carriers for Paclitaxel Delivery in the Treatment and Imaging of Colon Cancer in Mice [J].

Dehvari, Khalilalrahman ;

Chen, Yun ;

Tsai, Ya-Hui ;

Tseng, Sheng-Hong ;

Lin, Kuen-Song .

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2016, 12 (09) :1734-1745

[8] Forming double layer-encapsulated quantum dots for bio-imaging and cell targeting [J].

Fahmi, Mochamad Zakki ;

Chang, Jia-Yaw .

NANOSCALE, 2013, 5 (04) :1517-1528

[9] Zebrafish as a correlative and predictive model for assessing biomaterial nanotoxicity [J].

Fako, Valerie E. ;

Furgeson, Darin Y. .

ADVANCED DRUG DELIVERY REVIEWS, 2009, 61 (06) :478-486

[10] Hypocrellin-Loaded Gold Nanocages with High Two-Photon Efficiency for Photothermal/Photodynamic Cancer Therapy in Vitro [J].

Gao, Liang ;

Fei, Jinbo ;

Zhao, Jie ;

Li, Hong ;

Cui, Yue ;

Li, Junbai .

ACS NANO, 2012, 6 (09) :8030-8040

← 1 2 3 4 →