Wilms' tumor 1 (WT1) protein expression in human developing tissues

被引：28

作者：

Parenti, Rosalba ^{[1
]}

Salvatorelli, Lucia ^{[2
]}

Musumeci, Giuseppe ^{[3
]}

Parenti, Carmela ^{[4
]}

Giorlandino, Alexandra ^{[2
]}

Motta, Fabio ^{[2
]}

Magro, Gaetano ^{[2
]}

机构：

[1] Univ Catania, Sch Med, Physiol Sect, Dept Biomed & Biotechnol Sci, Catania, Italy

[2] Univ Catania, Azienda Osped Univ Policlin Vittorio Emanuele, Dept Med & Surg Sci & Adv Technol, GF Ingrassia,Anat Pathol Sect, I-95125 Catania, Italy

[3] Univ Catania, Sch Med, Dept Biomed & Biotechnol Sci, Human Anat & Histol Sect, I-95125 Catania, Italy

[4] Univ Catania, Dept Drug Sci, Pharmacol & Toxicol Sect, I-95125 Catania, Italy

来源：

ACTA HISTOCHEMICA | 2015年 / 117卷 / 4-5期

关键词：

WT1; Development; Oncofetal; Immunohistochemistry; Human; CENTRAL-NERVOUS-SYSTEM; SUPPRESSOR GENE WT1; NEURAL STEM-CELLS; PEDIATRIC RENAL TUMORS; FETAL MONKEY NEOCORTEX; RADIAL GLIAL-CELLS; IMMUNOHISTOCHEMICAL DETECTION; SYMPATHETIC NEUROBLASTS; VASCULAR MALFORMATIONS; SUBVENTRICULAR ZONE;

D O I：

10.1016/j.acthis.2015.03.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Several genes playing crucial roles in human development often reproduce a key role also during the onset and progression of malignant tumors. WT1, a transcription factor expressed with a dynamic pattern during human development, has either oncogenic or suppressor tumor properties. A detailed analysis of the immunohistochemical profile of WT1 protein in human developmental tissues could be exploitable as the rational for better understanding its role in cancerogenesis and planning innovative WT1-based therapeutic approaches. This review focuses on the dynamic immunohistochemical expression and distribution of WT1 protein during human ontogenesis, providing illustrations and discussion on the most relevant findings. The possibility that WT1 nuclear/cytoplasmic expression in some tumors mirrors its normal developmental regulation will be emphasized. (C) 2015 Elsevier GmbH. All rights reserved.

引用

页码：386 / 396

页数：11

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