Comparison of the percentages of CD4+ CD25high FOXP3+, CD4+ CD25low FOXP3+, and CD4+ FOXP3+ Tregs, in the umbilical cord blood of babies born to mothers with and without preeclampsia

被引：7
作者：
El-Chennawi, Farha [1 ]
Rageh, Ibrahim Mohamed [2 ]
Mansour, Amira Ibrahim [2 ]
Darwish, Mohammed Ibrahim [1 ]
Elghzaly, Ashraf Antar [1 ]
Sakr, Basma El Sayed [3 ]
Elbaz, Khaled Mohsen [4 ]
机构：
[1] Mansoura Univ, Clin & Chem Pathol Dept, Fac Med, Mansoura, Egypt
[2] Benha Univ, Clin & Chem Pathol Dept, Fac Med, Banha, Egypt
[3] Benha Univ, Gynecol & Obstet Dept, Fac Med, Banha, Egypt
[4] Benha Univ, Fac Med, Banha, Egypt
来源：
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 2017年 / 78卷 / 06期
关键词：
flow cytometry; FOXP3; preeclampsia; regulatory T cells; umbilical cord blood; REGULATORY T-CELLS; PERIPHERAL-BLOOD; PREGNANCY; TOLERANCE; EXPRESSION; QUESTIONS; SUBSETS; ANTIGEN; GENE;
D O I：
10.1111/aji.12761
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Problem: Little is known about how preeclampsia affects regulatory T-cell count and functions in umbilical cord blood of babies born to preeclamptic mothers. Here, we analyze the percentage of CD4(+) CD25(high) FOXP3(+), CD4(+) CD25(low) FOXP3(+), and CD4(+) FOXP3(-) Tregs, in the umbilical cord blood of babies born to mothers with and without preeclampsia. Method of study: The percentage of umbilical cord blood CD4(+) CD25(high) FOXP3(+), CD4(+) CD25(low) FOXP3(+), and CD4(+) FOXP3(+) Tregs were analyzed by flow cytometry. Results: CD4(+) CD25(high) FOXP3(+) Treg (%) and CD4(+) FOXP3(+) Treg (%) were significantly lower, while CD4(+) CD25(low) (%) was significantly higher in umbilical cord blood of babies born to preeclamptic mothers. Conclusion: Preeclampsia is associated with immune dysregulation which leads to a deficiency in Treg (CD4(+) CD25(high) FOXP3(+)) in the umbilical cord blood of babies born to preeclamptic mothers.
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页数：7
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