Synthesis and anti-inflammatory activity of some new nand S-alkylated arylidene-thioxo-imidazolidinones

被引：0

作者：

Santos, LC ^{[1
]}

Mourao, RHV

Uchoa, FT

Silva, TG

Malta, DJN

Moura, RO

Lima, MCA

Galdino, SL

Pitta, IR

Barbe, J

机构：

[1] Univ Fed Pernambuco, Dept Antibiot 50, BR-670901 Recife, PE, Brazil

[2] Univ Mediterranee, Fac Pharm, CNRS, UMR 6178,GERCTOP, F-13385 Marseille, France

来源：

HETEROCYCLIC COMMUNICATIONS | 2005年 / 11卷 / 05期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New arylidene-thioxo-imidazolidinones and S-alkylated arylidene-imidazolidinone derivatives were prepared from substituted 2-thioxo-imidazolidin4-one by nucleophilic addition of cyanoacrylates. N and S-alkylation was achieved treating 5-arylidene-2-thioxo-imidazolidin4-ones with benzyl or phenyloxoethyl chlorides under alkaline conditions. The anti-inflammatory activity of the synthesized imidazolidines was evaluated by the air pouch test and the carrageenan-induced paw edema test.

引用

页码：433 / 440

页数：8

共 12 条

[1] ALBUQUERQUE JFC, 1995, PHARMAZIE, V50, P387
[2] Andrade A M C, 2002, Boll Chim Farm, V141, P428
[3] SOME ANALOGS OF 3-BENZYLRHODANINE
BRADSHER, CK
BROWN, FC
SINCLAIR, EF
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1956, 78 (23) : 6189 - 6192
[4] Brandao S S, 2000, Boll Chim Farm, V139, P54
[5] Brandao SSF, 2004, HETEROCYCL COMMUN, V10, P9
[6] DELUCA RR, 1996, MANUAL PARA TECNIAS
[7] GOSSELIN GH, 1976, CLIN TOXICOLOGY COMM
[8] Guarda V. L. M., 2003, SULFUR LETT, V26, P17, DOI [10.1080/0278611021000048712, DOI 10.1080/0278611021000048712]
[9] EFFECT OF ROLIPRAM IN A MURINE MODEL OF ACUTE-INFLAMMATION - COMPARISON WITH THE CORTICOID DEXAMETHASONE
KLEMM, P
HARRIS, HJ
PERRETTI, M
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1995, 281 (01) : 69 - 74
[10] Oliveira Silvania M., 2004, Acta Farmaceutica Bonaerense, V23, P343

← 1 2 →