Bioavailability of docosahexaenoic acid 22:6(n-3) from enantiopure triacylglycerols and their regioisomeric counterpart in rats

被引：25

作者：

Linderborg, Kaisa M. ^{[1
]}

Kulkarni, Amruta ^{[1
]}

Zhao, Ai ^{[2
]}

Zhang, Jian ^{[2
]}

Kallio, Heikki ^{[1
]}

Magnusson, Johann D. ^{[3
]}

Haraldsson, Gudmundur G. ^{[3
]}

Zhang, Yumei ^{[2
]}

Yang, Baoru ^{[1
]}

机构：

[1] Univ Turku, Dept Biochem, Food Chem & Food Dev, Turku, Finland

[2] Peking Univ, Sch Publ Hlth, Hlth Sci Ctr, Dept Nutr & Food Hyg, Beijing, Peoples R China

[3] Univ Iceland, Inst Sci, Reykjavik, Iceland

来源：

FOOD CHEMISTRY | 2019年 / 283卷

基金：

中国国家自然科学基金; 芬兰科学院;

关键词：

Absorption; Docosahexaenoic acid; (n-3) PUFAs; Plasma and fecal lipids; Stearic acid; Enantiospecificity; Regiospecificity; Structured lipids; POLYUNSATURATED FATTY-ACIDS; STRUCTURED TRIACYLGLYCEROLS; OLEIC-ACID; CHEMOENZYMATIC SYNTHESIS; POSITIONAL DISTRIBUTION; INTESTINAL-ABSORPTION; LYMPHATIC ABSORPTION; LIPID-METABOLISM; DIETARY CALCIUM; SN-2; POSITION;

D O I：

10.1016/j.foodchem.2018.12.130

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Lack of synthetic enantiospecific triacylglycerols (TAGs) has hindered our understanding of the impact of TAG structure on the absorption and metabolic fate of fatty acids (FAs). In a five-day feeding trial with mildly (n-3) deficient rats, the bioavailability of docosahexaenoic acid [22:6(n-3), DHA] and stearic acid (18:0) from the two different enantiomers of TAG: sn-22:6(n-3)-18:0-18:0 and sn-18:0-18:0-22:6(n-3), and their regioisomeric TAG: sn-18:0-22:6(n-3)-18:0 was compared. Less secretion of fecal DHA was detected from the sn-2 position compared with the sn-1 and sn-3 positions, but no difference was found in DHA content of the fasting plasma or in the weight of the body or organs. 18:0 was lost to feces mainly as cleaved from the primary positions but also as glycerol-bound. The 5-day intervention in rats was long enough to modify the fatty acid profile of plasma phospholipids.

引用

页码：381 / 389

页数：9

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