Bioavailability of docosahexaenoic acid 22:6(n-3) from enantiopure triacylglycerols and their regioisomeric counterpart in rats

被引：25
作者：
Linderborg, Kaisa M. [1 ]
Kulkarni, Amruta [1 ]
Zhao, Ai [2 ]
Zhang, Jian [2 ]
Kallio, Heikki [1 ]
Magnusson, Johann D. [3 ]
Haraldsson, Gudmundur G. [3 ]
Zhang, Yumei [2 ]
Yang, Baoru [1 ]
机构：
[1] Univ Turku, Dept Biochem, Food Chem & Food Dev, Turku, Finland
[2] Peking Univ, Sch Publ Hlth, Hlth Sci Ctr, Dept Nutr & Food Hyg, Beijing, Peoples R China
[3] Univ Iceland, Inst Sci, Reykjavik, Iceland
来源：
FOOD CHEMISTRY | 2019年 / 283卷
基金：
中国国家自然科学基金; 芬兰科学院;
关键词：
Absorption; Docosahexaenoic acid; (n-3) PUFAs; Plasma and fecal lipids; Stearic acid; Enantiospecificity; Regiospecificity; Structured lipids; POLYUNSATURATED FATTY-ACIDS; STRUCTURED TRIACYLGLYCEROLS; OLEIC-ACID; CHEMOENZYMATIC SYNTHESIS; POSITIONAL DISTRIBUTION; INTESTINAL-ABSORPTION; LYMPHATIC ABSORPTION; LIPID-METABOLISM; DIETARY CALCIUM; SN-2; POSITION;
D O I：
10.1016/j.foodchem.2018.12.130
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Lack of synthetic enantiospecific triacylglycerols (TAGs) has hindered our understanding of the impact of TAG structure on the absorption and metabolic fate of fatty acids (FAs). In a five-day feeding trial with mildly (n-3) deficient rats, the bioavailability of docosahexaenoic acid [22:6(n-3), DHA] and stearic acid (18:0) from the two different enantiomers of TAG: sn-22:6(n-3)-18:0-18:0 and sn-18:0-18:0-22:6(n-3), and their regioisomeric TAG: sn-18:0-22:6(n-3)-18:0 was compared. Less secretion of fecal DHA was detected from the sn-2 position compared with the sn-1 and sn-3 positions, but no difference was found in DHA content of the fasting plasma or in the weight of the body or organs. 18:0 was lost to feces mainly as cleaved from the primary positions but also as glycerol-bound. The 5-day intervention in rats was long enough to modify the fatty acid profile of plasma phospholipids.
引用
收藏
页码：381 / 389
页数：9
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