An esterase-activatable curcumin prodrug for tumor-targeting therapy

被引：3
|
作者：
Liu, Li [1 ]
Zhang, Lele [1 ]
Tao, Menglin [1 ]
Wang, Minghui [1 ]
Dong, Ling [2 ]
Hai, Zijuan [1 ]
机构：
[1] Anhui Univ, Key Lab Struct & Funct Regulat Hybrid Mat, Minist Educ, Inst Phys Sci & Informat Technol, Hefei 230601, Anhui, Peoples R China
[2] Hefei Normal Univ, Dept Chem & Chem Engn, Hefei 230601, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2022年 / 58卷 / 96期
基金：
中国国家自然科学基金;
关键词：
CANCER; ALPHA(V)BETA(3); NANOPARTICLES; PH;
D O I：
10.1039/d2cc03952d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A tumor-targeting therapy strategy is urgently needed to increase the accumulation of drugs in tumors and reduce the side effects in normal tissues. Herein, we developed an esterase-activatable curcumin prodrug Cur-RGD for tumor-targeting therapy. Armed with the tumor-targeting RGD peptide and in situ esterase-triggered drug release, this prodrug Cur-RGD can efficiently improve the therapeutic effect of curcumin in tumors.
引用
收藏
页码：13329 / 13332
页数：4
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