Sesquiterpene and Norsesquiterpene Derivatives from Sanicula lamelligera and Their Biological Evaluation

被引：24

作者：

Li, Xue-Song ^{[1
,2
]}

Zhou, Xiao-Jiang ^{[2
]}

Zhang, Xing-Jie ^{[3
]}

Su, Jia ^{[1
]}

Li, Xue-Jing ^{[2
]}

Yan, Yong-Ming ^{[1
,4
]}

Zheng, Yong-Tang ^{[3
]}

Li, Yan ^{[1
]}

Yang, Liu-Meng ^{[3
]}

Cheng, Yong-Xian ^{[1
]}

机构：

[1] Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China

[2] Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China

[3] Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China

[4] Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 610075, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 06期

关键词：

CONSTITUENTS; TERPENOIDS; SAPONINS; LEAVES;

D O I：

10.1021/np200146x

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Fourteen sesquiterpene and norsesquiterpene derivatives, comprising six different carbon skeletons, were isolated from Sanicula lamelligera. Saniculamoid A1 (1a) is an oxidation product of saniculamoid A (1), created by the transition of a formyl group to a carboxylic acid group after a period of storage in air. The known compounds 5-14 were identified in Sanicula plants for the first time. The compounds were evaluated for their anti-HIV-1, cytostatic, and nitric-oxide-production-inhibiting activities using in vitro cellular assays. The results showed that 1,5-naphthalenediol inhibited nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 cells with an IC50 value of 28.1 mu M and was active toward five cancer cell lines with IC50 values in the 31.1-41.6 mu M range.

引用

页码：1521 / 1525

页数：5

共 29 条

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