New Insights into the Biology of Renal Cell Carcinoma

被引：56

作者：

Li, Lianjie ^{[1
,2
,3
]}

Kaelin, William G., Jr. ^{[1
,2
,3
]}

机构：

[1] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02215 USA

[2] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA

[3] Brigham & Womens Hosp, Boston, MA 02215 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2011年 / 25卷 / 04期

关键词：

Renal cell carcinoma; Clear-cell renal carcinoma; Hypoxia-inducible factor; HIF-responsive gene products; HYPOXIA-INDUCIBLE FACTOR; HIPPEL-LINDAU GENE; TUMOR-SUPPRESSOR PROTEIN; GROWTH-FACTOR RECEPTOR; HEPATOCYTE GROWTH; PRIMARY CILIUM; UP-REGULATION; MESENCHYMAL TRANSITION; HISTONE DEMETHYLASES; MONOCLONAL-ANTIBODY;

D O I：

10.1016/j.hoc.2011.04.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ninety percent or more of kidney cancers are believed to be of epithelial cell origin, and are referred to as renal cell carcinoma (RCC), which are further subdivided based on histology into clear-cell RCC (75%), papillary RCC (15%), chromophobe tumor (5%), and oncocytoma (5%). Some genes confer an increased risk of these various histologic RCC subtypes. In practice, there is some overlap among the histologic subtypes, and there are some shared molecular features among these tumor types. This review focuses primarily on the most common form of RCC, clear-cell renal carcinoma, noting some recent advances in the other histologic subtypes.

引用

页码：667 / +

页数：21

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