Relationships Between Cognitive Complaints and Quality of Life in Older Adults With Mild Cognitive Impairment, Mild Alzheimer Disease Dementia, and Normal Cognition

被引:96
作者
Stites, Shana D. [1 ]
Harkins, Kristin [2 ]
Rubright, Jonathan D. [5 ]
Karlawish, Jason [1 ,3 ,4 ]
机构
[1] Univ Penn, Perlman Sch Med, Dept Med Eth & Hlth Policy, 3615 Chestnut St, Philadelphia, PA 19104 USA
[2] Univ Penn, Dept Med, Philadelphia, PA 19104 USA
[3] Univ Penn, Penn Memory Ctr, Dept Med, Philadelphia, PA 19104 USA
[4] Univ Penn, Penn Memory Ctr, Dept Neurosurg, Philadelphia, PA 19104 USA
[5] Natl Board Med Examiners, Philadelphia, PA USA
关键词
self-rated health; Alzheimer disease; self-reported symptoms; mild cognitive impairment; quality of life; SUBJECTIVE MEMORY COMPLAINTS; DEPRESSIVE SYMPTOMS; NEUROPSYCHIATRIC SYMPTOMS; SELF; PEOPLE; RATINGS; DECLINE; TESTS; SCALE; AWARENESS;
D O I
10.1097/WAD.0000000000000262
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Purpose: To examine in persons with varying degrees of cognitive impairment the relationship between self-reports of cognitive complaints and quality of life (QOL). Methods: Older adults (n=259) with normal cognition, mild cognitive impairment (MCI), and mild stage Alzheimer disease (AD) dementia completed tests of cognition and self-report questionnaires about QOL and 3 kinds of cognitive complaints: cognitive difficulties, distress from cognitive difficulties, and believing you had more memory problems than most people. Bivariate, multivariable, and multivariate regression analyses assessed relationships between domains of QOL and each cognitive complaint. Results: Bivariate and multivariable analyses controlling for severity of cognitive and functional impairment found that cognitive complaints were related to relatively lower quality of daily life (QOL-AD, Dementia Quality of Life Scale), greater depression (GDS), more anxiety (BAI), higher perceived stress (PSS), and lower general mental well-being (SF-12 MCS). Discussion: Cognitive complaints have robust associations with QOL. These findings have implications for AD prevention trials and management of clinical populations.
引用
收藏
页码:276 / 283
页数:8
相关论文
共 62 条
[1]   Quality of life in patients with mild cognitive impairment [J].
Barrios, Helena ;
Narciso, Sofia ;
Guerreiro, Manuela ;
Maroco, Joao ;
Logsdon, Rebecca ;
de Mendonca, Alexandre .
AGING & MENTAL HEALTH, 2013, 17 (03) :287-292
[2]   AN INVENTORY FOR MEASURING CLINICAL ANXIETY - PSYCHOMETRIC PROPERTIES [J].
BECK, AT ;
BROWN, G ;
EPSTEIN, N ;
STEER, RA .
JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY, 1988, 56 (06) :893-897
[3]   Factors Associated with Self and Informant Ratings of the Quality of Life of People with Dementia Living in Care Facilities: A Cross Sectional Study [J].
Beer, Christopher ;
Flicker, Leon ;
Horner, Barbara ;
Bretland, Nick ;
Scherer, Samuel ;
Lautenschlager, Nicola T. ;
Schaper, Frank ;
Almeida, Osvaldo P. .
PLOS ONE, 2010, 5 (12)
[4]   Self-Rated Quality of Life in Mild Cognitive Impairment and Alzheimer's Disease The Problem of Affective Distortion [J].
Berwig, M. ;
Leicht, H. ;
Hartwig, K. ;
Gertz, H. J. .
GEROPSYCH-THE JOURNAL OF GERONTOPSYCHOLOGY AND GERIATRIC PSYCHIATRY, 2011, 24 (01) :45-51
[5]   Factors Impacting Quality of Life in Patients with Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD): A Cross-Sectional, Prospective Study in an Ambulatory Care Setting [J].
Brubaker, Sarah W. ;
Sapra, Mamta ;
Kim, Kye ;
Bradford, Lisa .
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 2016, 24 (03) :S82-S83
[6]  
Chang VT, 2000, CANCER, V89, P1162, DOI 10.1002/1097-0142(20000901)89:5<1162::AID-CNCR26>3.0.CO
[7]  
2-Y
[8]  
Chuang S.P., 2016, J MED SCI, V36, P14, DOI [10.4103/1011-4564.177171, DOI 10.4103/1011-4564.177171]
[9]   A GLOBAL MEASURE OF PERCEIVED STRESS [J].
COHEN, S ;
KAMARCK, T ;
MERMELSTEIN, R .
JOURNAL OF HEALTH AND SOCIAL BEHAVIOR, 1983, 24 (04) :385-396
[10]   A cross-sectional study of neuropsychiatric symptoms in 435 patients with Alzheimer's disease [J].
Craig, D ;
Mirakhur, A ;
Hart, DJ ;
McIlroy, SP ;
Passmore, AP .
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 2005, 13 (06) :460-468