Rimonabant: The first therapeutically relevant cannabinoid antagonist

被引：77
作者：
Carai, MAM
Colombo, G
Gessa, GL
机构：
[1] Univ Cagliari, Bb Brodie Dept Neurosci, I-09126 Cagliari, Italy
[2] CNR, Inst Neurosci, I-09126 Cagliari, Italy
来源：
LIFE SCIENCES | 2005年 / 77卷 / 19期
关键词：
rimonabant (SR 141716); cannabinoid CB1 receptor; drug addiction; food intake; body weight;
D O I：
10.1016/j.lfs.2005.04.017
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The present paper synthetically reviews the multiple experimental lines of evidence indicating the ability of the prototypic cannabinoid CB1, receptor antagonist, rimonabant (also known as SR 141716), to suppress the reinforcing/rewarding properties of different drugs of abuse, including cocaine, heroin, nicotine and alcohol, in laboratory rodents. This paper also reviews the data demonstrating that rimonabant reduces food intake and body weight in laboratory animals and humans. Taken together, the data reviewed here suggest that rimonabant may constitute a new and potentially effective medication for the treatment of drug addiction and obesity-related disorders. (c) 2005 Elsevier Inc. All rights reserved.
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收藏
页码：2339 / 2350
页数：12
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