Palladium(0)-Catalyzed Intermolecular Allylic Dearomatization of Indoles by a Formal [4+2] Cycloaddition Reaction

被引：44

作者：

Gao, Run-Duo ^{[1
]}

Xu, Qing-Long ^{[1
]}

Zhang, Bo ^{[1
]}

Gu, Yiting ^{[1
]}

Dai, Li-Xin ^{[1
]}

You, Shu-Li ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, 345 Lingling Lu, Shanghai 200032, Peoples R China

[2] Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300072, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2016年 / 22卷 / 33期

基金：

中国国家自然科学基金;

关键词：

asymmetric catalysis; dearomatization; indole; indoline; palladium; CATALYZED CASCADE REACTIONS; METHYL VINYL KETONE; 3-SUBSTITUTED INDOLES; ENANTIOSELECTIVE CONSTRUCTION; ASYMMETRIC DEAROMATIZATION; PROPARGYL CARBONATE; N-ALLOC; ACCESS; PYRROLOINDOLINES; ALLYLATION;

D O I：

10.1002/chem.201602691

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Bridged indoline derivatives were synthesized by an intermolecular Pd-catalyzed allylic dearomatization reaction of substituted indoles. The reaction between indoles and allyl carbonates bearing a nucleophilic alcohol side-chain proceeds in a cascade fashion, providing bridged indolines in excellent enantioselectivity.

引用

页码：11601 / 11604

页数：4

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