Evaluation of substance-P toxicity with single dose and repeated dose in rats

被引：13

作者：

Hong, Hyun Sook ^{[1
]}

Lim, Sung Vin ^{[2
]}

Son, Youngsook ^{[3
,4
]}

机构：

[1] Kyung Hee Univ, East West Med Res Inst, Coll Med, Seoul 130702, South Korea

[2] Kyung Hee Univ, Sch Med, Dept Clin Pharmacol, Seoul 130702, South Korea

[3] Kyung Hee Univ, Coll Life Sci, Dept Genet Engn, Yongin 441706, South Korea

[4] Kyung Hee Univ, Grad Sch Biotechnol, Yongin 441706, South Korea

来源：

MOLECULAR & CELLULAR TOXICOLOGY | 2015年 / 11卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

Single- and repeated-dose toxicity; Intravenous administration; Substance P; Rats; SPINAL-CORD-INJURY; ENDOTHELIAL-CELLS; PROLIFERATION; IRRADIATION; EXPRESSION; MODEL;

D O I：

10.1007/s13273-015-0019-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Toxicity study evaluating the effects of intravenous injection of SP with single- and repeated-dose in rats was performed. Single 100, 50, and 10 mg/kg doses of SP were administered and animals were monitored for 14 days. Although 10 mg/kg dose did not affect behavior and survival, 100 and 50 mg/kg doses elicited mortality, suggesting the minimum lethal dose (MLD) of SP to be between 10 and 50 mg/kg. To evaluate the toxicity of repeated dosing, rats were injected twice first two days per week with 30, 10, and 3 mg/kg of SP over 2 weeks and evaluated for survival, behavior, hematological factors, and organ weight. All rats administered with 10 and 3 mg/kg SP survived with minor changes in behavior and hematological indices. Thus, certain poison dose was estimated to be approximately 3 mg/kg, indicating that application of SP below 3 mg/kg may not be associated with toxicity.

引用

页码：201 / 211

页数：11