Pathophysiology of anaphylaxis

被引：70
作者：
Khan, Bilal Q.
Kemp, Stephen F. [1 ,2 ]
机构：
[1] Univ Mississippi, Med Ctr, Dept Med, Div Clin Immunol & Allergy, Jackson, MS 39216 USA
[2] Univ Mississippi, Med Ctr, Dept Pediat, Div Clin Immunol & Allergy, Jackson, MS 39216 USA
来源：
CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY | 2011年 / 11卷 / 04期
关键词：
anaphylaxis; bradycardia; mechanisms; pathophysiology; PLATELET-ACTIVATING-FACTOR; GENE-RELATED PEPTIDE; NITRIC-OXIDE; RECEPTOR ANTAGONISTS; CARDIAC ANAPHYLAXIS; ALLERGIC RESPONSES; HISTAMINE; SHOCK; MECHANISMS; PAF;
D O I：
10.1097/ACI.0b013e3283481ab6
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Purpose of review This review aims to provide an overview of the evolving understanding of the pathophysiology of anaphylaxis. Recent findings Immunopathologic mechanisms of anaphylaxis have traditionally focused on the IgE-dependent and IgE-independent release of mediators from mast cells and basophils. There are accumulating data supporting the significance of alternative pathways of anaphylaxis. Increasing attention has also focused on the internal compensatory mechanisms activated in response to anaphylaxis. Summary Recent advances will enhance understanding of the pathophysiology of anaphylaxis and might have future implications for diagnosis and management.
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收藏
页码：319 / 325
页数：7
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