Predictive factors of invasion in ductal carcinoma in situ diagnosed by core-needle biopsy

被引:0
|
作者
Villegas-Carlos, Felipe [1 ]
Andino-Araque, Veronica [2 ]
Valverde-Quintana, Margarita [3 ]
Larios-Cru, Kictzia Y. [4 ]
Perez-Gonzalez, Yosef [1 ]
Solano-Perez, Juan J. [1 ]
Ruvalcaba-Limon, Eva [1 ]
机构
[1] Fdn Canc Mama AC FUCAM, Dept Breast Surg Oncol, Mexico City, DF, Mexico
[2] Ctr Med Hosp Axxis, Dept Mastol, Quito, Ecuador
[3] Fdn Canc Mama AC FUCAM, Dept Pathol, Mexico City, DF, Mexico
[4] Fdn Canc Mama AC FUCAM, Dept Radiol & Imaging, Mexico City, DF, Mexico
来源
CIRUGIA Y CIRUJANOS | 2022年 / 90卷 / 01期
关键词
Ductal carcinoma in situ;   Predictive factors; Microinvasive carcinoma; LYMPH-NODE BIOPSY; BREAST-CANCER; NATURAL-HISTORY; METASTASIS; MICROINVASION; RECURRENCE; MANAGEMENT; FEATURES; DCIS;
D O I
10.24875/CIRU.21000136
中图分类号
R61 [外科手术学];
学科分类号
摘要
Objective: To identify clinical, radiological, and histopathological characteristics that could be predictive factors of microinvasive/ invasive breast carcinoma in patients with diagnosis of ductal carcinoma in situ (DCIS) by core-needle biopsy. Material and methods: This is a retrospective study conducted from 2006-2017, which included women _18 years of age with initial DCIS, and who were treated with surgery. Final diagnosis was divided in DCIS and microinvasive/invasive carcinoma. Results: 334 patients were included: 193 (57.8%) with DCIS and 141 (42.2%) with microinvasive/invasive carcinoma (microinvasive 5.1%, invasive 37.1%). Lymph node metastasis occurred in 16.3%. Differences between DCIS and microinvasive/invasive groups included the presence of palpable nodule (36.7% vs. 63.2%), radiological nodule (29% vs. 51%), bigger radiological-tumor size (1.2 cm vs. 1.7 cm), and larger microcalcification extension (2.5 cm vs. 3.1 cm), all of these variables p <= 0.05. Hormonal receptors and HER2 expression were similar. After logistic regression analysis, predictive factor of invasion was the presence of palpable nodule (OR = 4.072, 95%CI = 2.520-6.582, p <0.001) and radiological multicentric disease (OR = 1.677, 95%CI = 1.036-2.716, p = 0.035). Conclusions: In patients with DCIS, palpable nodule, and radiological multicentric disease, upgrade to microinvasive/invasive is high, and sentinel lymph node is recommended.
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页码:41 / 49
页数:9
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