Quaternary ammonium poly(diethylaminoethyl methacrylate) possessing antimicrobial activity

被引：28
作者：
Farah, Shady [1 ,2 ]
Aviv, Oren [1 ,2 ,3 ]
Laout, Natalia [3 ]
Ratner, Stanislav [3 ]
Beyth, Nurit [4 ]
Domb, Abraham J. [1 ,2 ]
机构：
[1] Hebrew Univ Jerusalem, Ctr Nanosci & Nanotechnol, Fac Med, Inst Drug Res,Sch Pharm, IL-91120 Jerusalem, Israel
[2] Hebrew Univ Jerusalem, Alex Grass Ctr Drug Design & Synth, IL-91120 Jerusalem, Israel
[3] Strauss Water Co, R&D Labs, Petah Tiqwa, Israel
[4] Hebrew Univ Jerusalem Hadassah Hosp & Med Sch, Fac Dent, Dept Prosthodont, IL-91120 Jerusalem, Israel
来源：
COLLOIDS AND SURFACES B-BIOINTERFACES | 2015年 / 128卷
关键词：
Diethylaminoethyl methacrylate; Quaternary ammonium (QA) polymers; Antimicrobial nanoparticles; Antimicrobial surfaces; POLYMERS;
D O I：
10.1016/j.colsurfb.2015.01.051
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Quaternary ammonium (QA) methacrylate monomers and polymers were synthesized from a N-alkylation of N,N-diethylaminoethyl methacrylate (DEAEM) monomer. Linear copolymers, and for the first time reported crosslinked nanoparticles (NPs), based QA-PDEAEM were prepared by radical polymerization of the quaternized QA-DEAEM monomers with either methyl methacrylate (MMA) or a divinyl monomer. QA-PDEAEM NPs of 50-70 nm were embedded in polyethylene vinyl acetate coating. QA-polymers with N-C-8 and N-C-18 alkyl chains and copolymers with methyl methacrylate were prepared at different molar ratios and examined for their antimicrobial effectiveness. These coatings exhibited strong antibacterial activity against four representative Gram-positive and Gram-negative bacteria. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：608 / 613
页数：6
相关论文
共 22 条
  • [1] Cotton, 1964, PROGR INORGANIC CHEM
  • [2] Fang M., 2008, J ORAL SCI, V3, P323
  • [3] Antimicrobial silica particles loaded with quaternary ammonium polyethyleneimine network
    Farah, Shady
    Aviv, Oren
    Laout, Natalia
    Ratner, Stanislav
    Beyth, Nurit
    Domb, Abraham J.
    [J]. POLYMERS FOR ADVANCED TECHNOLOGIES, 2014, 25 (06) : 689 - 692
  • [4] Crosslinked QA-PEI nanoparticles: synthesis reproducibility, chemical modifications, and stability study
    Farah, Shady
    Khan, Wahid
    Farber, Ira
    Kesler-Shvero, Dana
    Beyth, Nurit
    Weiss, Ervin I.
    Domb, Abraham J.
    [J]. POLYMERS FOR ADVANCED TECHNOLOGIES, 2013, 24 (05) : 446 - 452
  • [5] Studies on the preparation and antibacterial properties of quaternized polyethyleneimine
    Gao, Baojiao
    Zhang, Xin
    Zhu, Yong
    [J]. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2007, 18 (05) : 531 - 544
  • [6] Antibacterial surfaces: the quest for a new generation of biomaterials
    Hasan, Jafar
    Crawford, Russell J.
    Lvanova, Elena P.
    [J]. TRENDS IN BIOTECHNOLOGY, 2013, 31 (05) : 31 - 40
  • [7] Biologically active polymers.: V.: Synthesis and antimicrobial activity of modified poly(glycidyl methacrylate-co-2-hydroxyethyl methacrylate) derivatives with quaternary ammonium and phosphonium salts
    Kenawy, ER
    Abdel-Hay, FI
    El-Shanshoury, AERR
    El-Newehy, MH
    [J]. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2002, 40 (14) : 2384 - 2393
  • [8] Biologically active polymers: Modification and anti-microbial activity of chitosan derivatives
    Kenawy, ER
    Abdel-Hay, FI
    Abou El-Magd, A
    Mahmoud, Y
    [J]. JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, 2005, 20 (01) : 95 - 111
  • [9] Biologically active polymers, 6 - Synthesis and antimicrobial activity of some linear copolymers with quaternary ammonium and phosphonium groups
    Kenawy, ER
    Mahmoud, YAG
    [J]. MACROMOLECULAR BIOSCIENCE, 2003, 3 (02) : 107 - 116
  • [10] Mechanism of bactericidal and fungicidal activities of textiles covalently modified with alkylated polyethylenimine
    Lin, J
    Qiu, SY
    Lewis, K
    Klibanov, AM
    [J]. BIOTECHNOLOGY AND BIOENGINEERING, 2003, 83 (02) : 168 - 172
123