COVID-19: a case for inhibiting IL-17?

被引：220

作者：

Pacha, Omar ^{[1
]}

Sallman, Mary Alice ^{[2
]}

Evans, Scott E. ^{[3
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Dermatol, Houston, TX 77030 USA

[2] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Dermatol, Houston, TX 77030 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Pulm Med, Houston, TX 77030 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2020年 / 20卷 / 06期

关键词：

D O I：

10.1038/s41577-020-0328-z

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IL-17 and IL-17 receptor inhibitors boast an impressive safety history and are widely available. Here, we argue that targeting IL-17 is immunologically plausible as a strategy to prevent acute respiratory distress syndrome (ARDS) in coronavirus disease 2019 (COVID-19) and discuss why we think that a clinical trial of a drug in this class could be a logical addition to the effort to find effective therapies.

引用

页码：345 / 346

页数：2

共 10 条

[1]

[Anonymous], 2020, 2019 NOVEL CORONAVIR

[2] Critical Role of IL-17RA in Immunopathology of Influenza Infection [J].

Crowe, Christopher R. ;

Chen, Kong ;

Pociask, Derek A. ;

Alcorn, John F. ;

Krivich, Cameron ;

Enelow, Richard I. ;

Ross, Ted M. ;

Witztum, Joseph L. ;

Kolls, Jay K. .

JOURNAL OF IMMUNOLOGY, 2009, 183 (08) :5301-5310

[3] Influenza A Inhibits Th17-Mediated Host Defense against Bacterial Pneumonia in Mice [J].

Kudva, Anupa ;

Scheller, Erich V. ;

Robinson, Keven M. ;

Crowe, Chris R. ;

Choi, Sun Mi ;

Slight, Samantha R. ;

Khader, Shabaana A. ;

Dubin, Patricia J. ;

Enelow, Richard I. ;

Kolls, Jay K. ;

Alcorn, John F. .

JOURNAL OF IMMUNOLOGY, 2011, 186 (03) :1666-1674

[4] Blockade of Interleukin-17 Restrains the Development of Acute Lung Injury [J].

Li, Q. ;

Gu, Y. ;

Tu, Q. ;

Wang, K. ;

Gu, X. ;

Ren, T. .

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2016, 83 (03) :203-211

[5] MERS-CoV infection in humans is associated with a pro-inflammatory Th1 and Th17 cytokine profile [J].

Mahallawi, Waleed H. ;

Khabour, Omar F. ;

Zhang, Qibo ;

Makhdoum, Hatim M. ;

Suliman, Bandar A. .

CYTOKINE, 2018, 104 :8-13

[6] COVID-19: consider cytokine storm syndromes and immunosuppression [J].

Mehta, Puja ;

McAuley, Daniel F. ;

Brown, Michael ;

Sanchez, Emilie ;

Tattersall, Rachel S. ;

Manson, Jessica J. .

LANCET, 2020, 395 (10229) :1033-1034

[7] Innate Lymphoid Cells Are the Predominant Source of IL-17A during the Early Pathogenesis of Acute Respiratory Distress Syndrome [J].

Muir, Roshell ;

Osbourn, Megan ;

Dubois, Alice V. ;

Doran, Emma ;

Small, Donna M. ;

Monahan, Avril ;

O'Kane, Cecilia M. ;

McAllister, Katherine ;

Fitzgerald, Denise C. ;

Kissenpfennig, Adrien ;

McAuley, Daniel F. ;

Ingram, Rebecca J. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2016, 193 (04) :407-416

[8] Cardiac myosin-Th17 responses promote heart failure in human myocarditis [J].

Myers, Jennifer M. ;

Cooper, Leslie T. ;

Kem, David C. ;

Stavrakis, Stavros ;

Kosanke, Stanley D. ;

Shevach, Ethan M. ;

Fairweather, DeLisa ;

Stoner, Julie A. ;

Cox, Carol J. ;

Cunningham, Madeleine W. .

JCI INSIGHT, 2016, 1 (09)

[9]

Xie MM, 2019, BIOSCIENCE REP, V39, DOI [10.1042/BSR20181987, 10.1042/bsr20181987]

[10]

Yang X., 2020, LANCET RESP MED, V8, P475, DOI [10.1016/S2213-2600(20)30079-5, DOI 10.1016/S2213-2600(20)30079-5]

← 1 →