Synthesis and properties of novel pyrrolidinyl PNA carrying β-amino acid spacers

被引：39

作者：

Vilaivan, T

Suparpprom, C

Harnyuttanakorn, P

Lowe, G

机构：

[1] Chulalongkorn Univ, Fac Sci, Dept Chem, Organ Synth Res Unit, Bangkok 10330, Thailand

[2] Chulalongkorn Univ, Fac Sci, Dept Biol, Bangkok 10330, Thailand

[3] Univ Oxford, Dyson Perrins Lab, Dept Chem, Oxford OX1 3QY, England

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 32期

关键词：

nucleic acids; DNA; mimetics; beta-amino acids;

D O I：

10.1016/S0040-4039(01)01020-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel pyrrolidinyl peptide nucleic acids comprising alternate sequences of nucleobase-modified D-proline and beta -amino acid spacers selected from L-aminopyrrolidine-2-carboxylic acid, D-aminopyrrolidine-2-carboxylic acid, (1R,2S)-2-aminocyclopentane carboxylic acid and P-alanine were synthesized using solid phase methodology. Gel-binding shift assay revealed that only the homothymine PNA decamer bearing D-aminopyrrolidine-2-carboxylic acid spacer binds with (dA)(10). (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：5533 / 5536

页数：4

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