Synthetic developments towards PNA-peptide conjugates

被引：30
作者：
de Koning, MC [1 ]
van der Marel, GA [1 ]
Overhand, M [1 ]
机构：
[1] Leiden Univ, Leiden Inst Chem, NL-2300 RA Leiden, Netherlands
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 2003年 / 7卷 / 06期
关键词：
D O I：
10.1016/j.cbpa.2003.10.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Since the discovery of peptide nucleic acids (PNAs) as DNA mimics in the early 1990s, a tremendous effort has been directed to their application as antisense and antigene probes. With the aim of further enhancing their properties, PNAs have been conjugated to a variety of effector molecules. Among these, small peptide fragments, often derived from functional proteins, are able to convey their specific properties to the conjugate.
引用
收藏
页码：734 / 740
页数：7
相关论文
共 50 条
  • [1] Synthesis of PNA-peptide conjugates and their interactions with DNA
    Balasundaram, G
    Takahashi, T
    Ueno, A
    Mihara, H
    PEPTIDES FOR THE NEW MILLENNIUM, 2000, : 790 - 791
  • [2] Synthesis and membrane permeability of PNA-peptide conjugates
    Simmons, CG
    Pitts, AE
    Mayfield, LD
    Shay, JW
    Corey, DR
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (23) : 3001 - 3006
  • [3] Antisense PNA and PNA-peptide conjugates for the modulation of the β-globin gene splicing
    Romanelli, A
    Pensato, S
    Di Niola, E
    Feriotto, G
    Breveglieri, G
    Zaccaro, L
    Saviano, M
    Gambari, R
    Pedone, C
    Benedetti, E
    BIOPOLYMERS, 2005, 80 (04) : 551 - 551
  • [4] Antisense PNA and PNA-peptide conjugates for the modulation of β-globin gene splicing
    Romanelli, Alessandra
    Pensato, Soccorsa
    Di Niola, Erminia
    Feriotto, Giordana
    Salvatori, Francesca
    Breveglieri, Giulia
    Zaccaro, Laura
    Saviano, Michele
    Gambari, Roberto
    Pedonel, Carlo
    Benedetti, Ettore
    UNDERSTANDING BIOLOGY USING PEPTIDES, 2006, : 367 - +
  • [5] Synthesis and cellular uptake of cell delivering PNA-peptide conjugates
    Díaz-Mochón, JJ
    Bialy, L
    Watson, J
    Sánchez-Martín, RM
    Bradley, M
    CHEMICAL COMMUNICATIONS, 2005, (26) : 3316 - 3318
  • [6] Photochemically induced gene silencing using PNA-peptide conjugates
    Boe, S.
    Hovig, E.
    OLIGONUCLEOTIDES, 2006, 16 (02) : 145 - 157
  • [7] Microwave-assisted orthogonal synthesis of PNA-peptide conjugates
    Svensen, Nina
    Diaz-Mochon, Juan Jose
    Bradley, Mark
    TETRAHEDRON LETTERS, 2008, 49 (46) : 6498 - 6500
  • [8] Cell-dependent differential cellular uptake of PNA, peptides, and PNA-peptide conjugates
    Koppelhus, U
    Awasthi, SK
    Zachar, V
    Holst, HU
    Ebbesen, P
    Nielsen, PE
    ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT, 2002, 12 (02): : 51 - 63
  • [9] Dde-protected PNA monomers, orthogonal to Fmoc, for the synthesis of PNA-peptide conjugates
    Bialy, L
    Díaz-Mochón, JJ
    Specker, E
    Keinicke, L
    Bradley, M
    TETRAHEDRON, 2005, 61 (34) : 8295 - 8305
  • [10] Inhibition of Growth and Gene Expression by PNA-peptide Conjugates in Streptococcus pyogenes
    Patenge, Nadja
    Pappesch, Roberto
    Krawack, Franziska
    Walda, Claudia
    Abu Mraheil, Mobarak
    Jacob, Anette
    Hain, Torsten
    Kreikemeyer, Bernd
    MOLECULAR THERAPY-NUCLEIC ACIDS, 2013, 2 : e132
12345