Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects

被引：82

作者：

Miyake, Kazuaki ^{[1
]}

Horikawa, Yukio ^{[2
,3
,4
]}

Hara, Kazuo ^{[5
]}

Yasuda, Kazuki ^{[6
]}

Osawa, Haruhiko ^{[7
]}

Furuta, Hiroto

Hirota, Yushi ^{[1
]}

Yamagata, Kazuya

Hinokio, Yoshinori

Oka, Yoshitomo

Iwasaki, Naoko

Iwamoto, Yasuhiko

Yamada, Yuichiro

Seino, Yutaka

Maegawa, Hiroshi

Kashiwagi, Atsunori

Yamamoto, Ken

Tokunaga, Katsushi

Takeda, Jun ^{[2
,3
]}

Makino, Hideichi ^{[7
]}

Nanjo, Kishio

Kadowaki, Takashi ^{[5
]}

Kasuga, Masato ^{[1
]}

机构：

[1] Kobe Univ, Grad Sch Med, Dept Internal Med, Div Endocrinol Diabet & Metab,Chuo Ku, Kobe, Hyogo 6500017, Japan

[2] Gifu Univ, Sch Med, Dept Diabet, Gifu 500, Japan

[3] Gifu Univ, Sch Med, Div Mol & Struct, Gifu 500, Japan

[4] Gunma Univ, Inst Mol & Cellular Regulat, Lab Med Genom, Biosignal Genome Resource Ctr, Maebashi, Gunma 371, Japan

[5] Univ Tokyo, Dept Metab Dis, Grad Sch Med, Tokyo, Japan

[6] Int Med Ctr Japan, Res Inst, Dept Metab Disorder, Tokyo, Japan

[7] Ehime Univ, Dept Mol & Med Genet, Grad Sch Med, Matsuyama, Ehime 790, Japan

来源：

JOURNAL OF HUMAN GENETICS | 2008年 / 53卷 / 02期

关键词：

type; 2; diabetes; polymorphism; beta-cell function; transcription factor 7-like 2 (TCF7L2); association study;

D O I：

10.1007/s10038-007-0231-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Transcription factor 7-like 2 (TCF7L2) has been shown to be associated with type 2 diabetes mellitus in multiple ethnic groups. Regarding the Asian population, Horikoshi et al. (Diabetologia 50:747-751, 2007) and Hayashi et al. (Diabetologia 50:980-984, 2007) reported that single nucleotide polymorphisms (SNPs) in TCF7L2 were associated with type 2 diabetes in the Japanese population, while contradictory results were reported for Han Chinese populations. The aim of this study was to investigate the associations of the TCF7L2 gene with type 2 diabetes using a relatively large sample size: 2,214 Japanese individuals with type 2 diabetes and 1,873 normal controls. The minor alleles of rs7903146, rs11196205, and rs12255372 showed significant associations with type 2 diabetes (OR = 1.48, P = 2.7 x 10(-4); OR = 1.39, P = 4.6 x 10(-4); OR = 1.70, P = 9.8 x 10(-5), respectively) in the combined sample sets. However, neither rs11196218 nor rs290487 showed a significant association. These results indicate that TCF7L2 is an important susceptibility gene for type 2 diabetes in the Japanese population.

引用

页码：174 / 180

页数：7

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