Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects

被引：81
作者：
Miyake, Kazuaki [1 ]
Horikawa, Yukio [2 ,3 ,4 ]
Hara, Kazuo [5 ]
Yasuda, Kazuki [6 ]
Osawa, Haruhiko [7 ]
Furuta, Hiroto
Hirota, Yushi [1 ]
Yamagata, Kazuya
Hinokio, Yoshinori
Oka, Yoshitomo
Iwasaki, Naoko
Iwamoto, Yasuhiko
Yamada, Yuichiro
Seino, Yutaka
Maegawa, Hiroshi
Kashiwagi, Atsunori
Yamamoto, Ken
Tokunaga, Katsushi
Takeda, Jun [2 ,3 ]
Makino, Hideichi [7 ]
Nanjo, Kishio
Kadowaki, Takashi [5 ]
Kasuga, Masato [1 ]
机构：
[1] Kobe Univ, Grad Sch Med, Dept Internal Med, Div Endocrinol Diabet & Metab,Chuo Ku, Kobe, Hyogo 6500017, Japan
[2] Gifu Univ, Sch Med, Dept Diabet, Gifu 500, Japan
[3] Gifu Univ, Sch Med, Div Mol & Struct, Gifu 500, Japan
[4] Gunma Univ, Inst Mol & Cellular Regulat, Lab Med Genom, Biosignal Genome Resource Ctr, Maebashi, Gunma 371, Japan
[5] Univ Tokyo, Dept Metab Dis, Grad Sch Med, Tokyo, Japan
[6] Int Med Ctr Japan, Res Inst, Dept Metab Disorder, Tokyo, Japan
[7] Ehime Univ, Dept Mol & Med Genet, Grad Sch Med, Matsuyama, Ehime 790, Japan
来源：
JOURNAL OF HUMAN GENETICS | 2008年 / 53卷 / 02期
关键词：
type; 2; diabetes; polymorphism; beta-cell function; transcription factor 7-like 2 (TCF7L2); association study;
D O I：
10.1007/s10038-007-0231-5
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Transcription factor 7-like 2 (TCF7L2) has been shown to be associated with type 2 diabetes mellitus in multiple ethnic groups. Regarding the Asian population, Horikoshi et al. (Diabetologia 50:747-751, 2007) and Hayashi et al. (Diabetologia 50:980-984, 2007) reported that single nucleotide polymorphisms (SNPs) in TCF7L2 were associated with type 2 diabetes in the Japanese population, while contradictory results were reported for Han Chinese populations. The aim of this study was to investigate the associations of the TCF7L2 gene with type 2 diabetes using a relatively large sample size: 2,214 Japanese individuals with type 2 diabetes and 1,873 normal controls. The minor alleles of rs7903146, rs11196205, and rs12255372 showed significant associations with type 2 diabetes (OR = 1.48, P = 2.7 x 10(-4); OR = 1.39, P = 4.6 x 10(-4); OR = 1.70, P = 9.8 x 10(-5), respectively) in the combined sample sets. However, neither rs11196218 nor rs290487 showed a significant association. These results indicate that TCF7L2 is an important susceptibility gene for type 2 diabetes in the Japanese population.
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收藏
页码：174 / 180
页数：7
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