Functional polymer-based siRNA delivery carrier that recognizes site-specific biosignals

被引：11
作者：
Takemoto, Hiroyasu [1 ]
Nishiyama, Nobuhiro [1 ,2 ]
机构：
[1] Tokyo Inst Technol, Inst Innovat Res, Lab Chem & Life Sci, Midori Ku, 4259 Nagatsuta, Yokohama, Kanagawa 2268503, Japan
[2] Kawasaki Inst Ind Promot, Innovat Ctr Nanomed iCONM, Kawasaki Ku, 3-25-14 Tonomachi, Kawasaki, Kanagawa 2100821, Japan
来源：
JOURNAL OF CONTROLLED RELEASE | 2017年 / 267卷
基金：
日本科学技术振兴机构;
关键词：
POLYION COMPLEX MICELLE; SILENCING IN-VIVO; DRUG-DELIVERY; SOLID TUMORS; BIOMEDICAL APPLICATIONS; GLOBULE TRANSITION; ATP CONCENTRATION; ENDOSOMAL ESCAPE; AMINO-GROUPS; GENE;
D O I：
10.1016/j.jconrel.2017.09.005
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Responsive molecular designs to specific biosignals in microenvironments endow site-specific functionalities with associated polymers. Thus, the construction of small interfering RNA (siRNA) carriers with functional polymers enables smart programs that are triggered by sequential biosignals in a pathway to the targeted cytosol for effective gene silencing. In this review, we explain rational strategies for the design of functional polymers with responsiveness to biosignals and describe the examples of smart carriers for siRNA delivery.
引用
收藏
页码：90 / 99
页数：10
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