Are low ultraviolet B and vitamin D associated with higher incidence of multiple myeloma?

被引：8

作者：

Mohr, Sharif B. ^{[1
,2
]}

Gorham, Edward D. ^{[1
,2
]}

Garland, Cedric F. ^{[1
]}

Grant, William B. ^{[3
]}

Garland, Frank C. ^{[1
,2
]}

Cuomo, Raphael E. ^{[1
,4
]}

机构：

[1] Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USA

[2] Naval Hlth Res Ctr, San Diego, CA USA

[3] Sunlight Nutr & Hlth Res Ctr, San Francisco, CA USA

[4] San Diego State Univ, Grad Sch Publ Hlth, San Diego, CA 92182 USA

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2015年 / 148卷

关键词：

Myeloma; Ultraviolet rays; Incidence; Vitamin D; Alcohol; Cigarettes; Multiple regression; International comparisons; INCIDENCE RATES; BREAST-CANCER; PLASMA; 25-HYDROXYVITAMIN-D; SERUM; RISK; IRRADIANCE; PREVENTION; 1,25-DIHYDROXYVITAMIN-D; COLON; SKIN;

D O I：

10.1016/j.jsbmb.2014.12.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: The purpose of this study was to determine whether an inverse association exists between latitude, solar ultraviolet B (UVB) irradiance, and incidence rates of multiple myeloma. Methods Associations of latitude and UVB irradiance with age-standardized incidence rates of multiple myeloma were analyzed for 175 countries while controlling for sex-specific obesity prevalence, cigarette consumption, and alcohol consumption using multiple linear regression. Results Incidence rates of multiple myeloma were greater at higher latitudes (R-2 for latitude for males = 0.31, p < 0.0001; females R-2=0.27, p < 0.0001). In regression models for males (R-2=0.62, p < 0.0001) and females (R-2=0.51, p < 0.0001), UVB irradiance was independently inversely associated with incidence rates. Conclusions Age-adjusted incidence rates of multiple myeloma were higher in countries with lower solar UVB irradiance. Further investigation is warranted in individuals of the association of prediagnostic serum 25 (OH)D with risk. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：245 / 252

页数：8

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