Are low ultraviolet B and vitamin D associated with higher incidence of multiple myeloma?

被引：8
作者：
Mohr, Sharif B. [1 ,2 ]
Gorham, Edward D. [1 ,2 ]
Garland, Cedric F. [1 ]
Grant, William B. [3 ]
Garland, Frank C. [1 ,2 ]
Cuomo, Raphael E. [1 ,4 ]
机构：
[1] Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USA
[2] Naval Hlth Res Ctr, San Diego, CA USA
[3] Sunlight Nutr & Hlth Res Ctr, San Francisco, CA USA
[4] San Diego State Univ, Grad Sch Publ Hlth, San Diego, CA 92182 USA
来源：
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2015年 / 148卷
关键词：
Myeloma; Ultraviolet rays; Incidence; Vitamin D; Alcohol; Cigarettes; Multiple regression; International comparisons; INCIDENCE RATES; BREAST-CANCER; PLASMA; 25-HYDROXYVITAMIN-D; SERUM; RISK; IRRADIANCE; PREVENTION; 1,25-DIHYDROXYVITAMIN-D; COLON; SKIN;
D O I：
10.1016/j.jsbmb.2014.12.005
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Background: The purpose of this study was to determine whether an inverse association exists between latitude, solar ultraviolet B (UVB) irradiance, and incidence rates of multiple myeloma. Methods Associations of latitude and UVB irradiance with age-standardized incidence rates of multiple myeloma were analyzed for 175 countries while controlling for sex-specific obesity prevalence, cigarette consumption, and alcohol consumption using multiple linear regression. Results Incidence rates of multiple myeloma were greater at higher latitudes (R-2 for latitude for males = 0.31, p < 0.0001; females R-2=0.27, p < 0.0001). In regression models for males (R-2=0.62, p < 0.0001) and females (R-2=0.51, p < 0.0001), UVB irradiance was independently inversely associated with incidence rates. Conclusions Age-adjusted incidence rates of multiple myeloma were higher in countries with lower solar UVB irradiance. Further investigation is warranted in individuals of the association of prediagnostic serum 25 (OH)D with risk. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：245 / 252
页数：8
相关论文
共 39 条
  • [21] PHOTOSYNTHESIS OF PREVITAMIN-D3 IN HUMAN-SKIN AND THE PHYSIOLOGIC CONSEQUENCES
    HOLICK, MF
    MACLAUGHLIN, JA
    CLARK, MB
    HOLICK, SA
    POTTS, JT
    ANDERSON, RR
    BLANK, IH
    PARRISH, JA
    [J]. SCIENCE, 1980, 210 (4466) : 203 - 205
  • [22] Effect of calcitriol and pamidronate in multiple myeloma
    Imseis, RE
    Palmieri, GMA
    Holbert, JM
    Leventhal, MR
    Sebes, JI
    [J]. AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 1999, 318 (01) : 61 - 66
  • [23] Jemal A, 2008, CANC FACTS FIGURES
  • [24] CHILDHOOD NERVOUS-SYSTEM TUMORS - AN ASSESSMENT OF RISK ASSOCIATED WITH PATERNAL OCCUPATIONS INVOLVING USE, REPAIR OR MANUFACTURE OF ELECTRICAL AND ELECTRONIC EQUIPMENT
    JOHNSON, CC
    SPITZ, MR
    [J]. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 1989, 18 (04) : 756 - 762
  • [25] Plasma 25-hydroxy vitamin D concentrations, vitamin D receptor genotype and breast cancer risk in a UK Caucasian population
    Lowe, LC
    Guy, M
    Mansi, JL
    Peckitt, C
    Bliss, J
    Wilson, RG
    Colston, KW
    [J]. EUROPEAN JOURNAL OF CANCER, 2005, 41 (08) : 1164 - 1169
  • [26] MOHR S, 2005, P ESRI INT US C REDL, P1468
  • [27] Is ultraviolet B irradiance inversely associated with incidence rates of endometrial cancer: an ecological study of 107 countries
    Mohr, Sharif B.
    Garland, Cedric F.
    Gorham, Edward D.
    Grant, William B.
    Garland, Frank C.
    [J]. PREVENTIVE MEDICINE, 2007, 45 (05) : 327 - 331
  • [28] Low Ultraviolet B and Increased Risk of Brain Cancer: An Ecological Study of 175 Countries
    Mohr, Sharif B.
    Gorham, Edward D.
    Garland, Cedric F.
    Grant, William B.
    Garland, Frank C.
    [J]. NEUROEPIDEMIOLOGY, 2010, 35 (04) : 281 - 290
  • [29] Ultraviolet B Irradiance and Vitamin D Status are Inversely Associated With Incidence Rates of Pancreatic Cancer Worldwide
    Mohr, Sharif B.
    Garland, Cedric F.
    Gorham, Edward D.
    Grant, William B.
    Garland, Frank C.
    [J]. PANCREAS, 2010, 39 (05) : 669 - 674
  • [30] Ultraviolet B Irradiance and Incidence Rates of Bladder Cancer in 174 Countries
    Mohr, Sharif B.
    Garland, Cedric F.
    Gorham, Edward D.
    Grant, William B.
    Garland, Frank C.
    [J]. AMERICAN JOURNAL OF PREVENTIVE MEDICINE, 2010, 38 (03) : 296 - 302
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