Duffy blood group gene polymorphisms among malaria vivax patients in four areas of the Brazilian Amazon region

被引：60

作者：

Cavasini, Carlos E. ^{[1
]}

de Mattos, Luiz C. ^{[2
]}

D'Almeida Couto, Alvaro A. R. ^{[3
]}

D'Almeida Couto, Vanja S. C. ^{[4
]}

Gollino, Yuri ^{[1
]}

Moretti, Laurence J. ^{[1
]}

Bonini-Domingos, Claudia R. ^{[5
]}

Rossit, Andrea R. B. ^{[1
]}

Castilho, Lilian ^{[6
]}

Machado, Ricardo L. D. ^{[1
]}

机构：

[1] Ctr Invest Microorganismos, Fac Med Sao Jose Rio Preto, BR-15090000 Sao Jose Dos Campos, Brazil

[2] Fac Med Sao Jose Rio Preto, Imunogenet Lab, Sao Jose Dos Campos, SP, Brazil

[3] SEAMA Fac, Macapa, Amapa State, Brazil

[4] Evandro Chagas Inst, Malaria Program, Belem, Para, Brazil

[5] UNESP, IBILCE, Hemoglobin Dis Lab, Sao Jose Dos Campos, SP, Brazil

[6] Univ Estadual Campinas, Campinas, SP, Brazil

来源：

MALARIA JOURNAL | 2007年 / 6卷 / 1期

关键词：

D O I：

10.1186/1475-2875-6-167

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Background: Duffy blood group polymorphisms are important in areas where Plasmodium vivax predominates, because this molecule acts as a receptor for this protozoan. In the present study, Duffy blood group genotyping in P. vivax malaria patients from four different Brazilian endemic areas is reported, exploring significant associations between blood group variants and susceptibility or resistance to malaria. Methods: The P. vivax identification was determined by non-genotypic and genotypic screening tests. The Duffy blood group was genotyped by PCR/RFLP in 330 blood donors and 312 malaria patients from four Brazilian Amazon areas. In order to assess the variables significance and to obtain independence among the proportions, the Fisher's exact test was used. Results: The data show a high frequency of the FYA/FYB genotype, followed by FYB/FYB, FYA/FYA, FYA/FYB-33 and FYB/FYB-33. Low frequencies were detected for the FYA/FYX, FYB/FYX, FYX/FYX and FYB-33/FYB-33 genotypes. Negative Duffy genotype (FYB-33/FYB-33) was found in both groups: individuals infected and non-infected (blood donors). No individual carried the FYX/FYB-33 genotype. Some of the Duffy genotypes frequencies showed significant differences between donors and malaria patients. Conclusion: The obtained data suggest that individuals with the FYA/FYB genotype have higher susceptibility to malaria. The presence of the FYB-33 allele may be a selective advantage in the population, reducing the rate of infection by P. vivax in this region. Additional efforts may contribute to better elucidate the physiopathologic differences in this parasite/host relationship in regions endemic for P. vivax malaria, in particular the Brazilian Amazon region.

引用

页数：8

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