OSTEOARTHRITIS Probing knee OA as a system responding to a stimulus

被引：24

作者：

Andriacchi, Thomas P. ^{[1
]}

机构：

[1] Stanford Univ, Dept Mech Engn, Stanford, CA 94305 USA

来源：

NATURE REVIEWS RHEUMATOLOGY | 2012年 / 8卷 / 07期

关键词：

BIOMARKERS; PAIN;

D O I：

10.1038/nrrheum.2012.59

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Systems level analysis using stimulus-response modelling could increase our understanding of the interplay between biochemical, structural and functional variables that influence the development and manifestation of osteoarthritis. Furthermore, surrogate markers of clinical responses identified might enable early diagnosis, improve therapy, and facilitate development of new treatments and end points.

引用

页码：371 / 372

页数：2

共 9 条

[1] Gait Mechanics Influence Healthy Cartilage Morphology and Osteoarthritis of the Knee [J].

Andriacchi, Thomas P. ;

Koo, Seungbum ;

Scanlan, Sean F. .

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 2009, 91A :95-101

[2] A framework for the in vivo pathomechanics of osteoarthritis at the knee [J].

Andriacchi, TP ;

Mündermann, A ;

Smith, RL ;

Alexander, EJ ;

Dyrby, CO ;

Koo, S .

ANNALS OF BIOMEDICAL ENGINEERING, 2004, 32 (03) :447-457

[3]

Erhart-Hledik J. C., 2012, 58 ANN M ORTH RES SO

[4] Systematic review of the concurrent and predictive validity of MRI biomarkers in OA [J].

Hunter, D. J. ;

Zhang, W. ;

Conaghan, Philip G. ;

Hirko, K. ;

Menashe, L. ;

Li, L. ;

Reichmann, W. M. ;

Losina, E. .

OSTEOARTHRITIS AND CARTILAGE, 2011, 19 (05) :557-588

[5]

Lo G. H., ARTHRITIS RHEUM

[6] THE ANTERIOR CRUCIATE LIGAMENT-DEFICIENT KNEE WITH VARUS ALIGNMENT - AN ANALYSIS OF GAIT ADAPTATIONS AND DYNAMIC JOINT LOADINGS [J].

NOYES, FR ;

SCHIPPLEIN, OD ;

ANDRIACCHI, TP ;

SADDEMI, SR ;

WEISE, M .

AMERICAN JOURNAL OF SPORTS MEDICINE, 1992, 20 (06) :707-716

[7] Recent advances in biomarkers in osteoarthritis [J].

Patra, Debabrata ;

Sandell, Linda J. .

CURRENT OPINION IN RHEUMATOLOGY, 2011, 23 (05) :465-470

[8] Psychosocial factors and the pain experience of osteoarthritis patients: new findings and new directions [J].

Somers, Tamara J. ;

Keefe, Francis J. ;

Godiwala, Neha ;

Hoyler, Georgia H. .

CURRENT OPINION IN RHEUMATOLOGY, 2009, 21 (05) :501-506

[9] Fluctuation of Knee Pain and Changes in Bone Marrow Lesions, Effusions, and Synovitis on Magnetic Resonance Imaging [J].

Zhang, Yuqing ;

Nevitt, Michael ;

Niu, Jingbo ;

Lewis, Cora ;

Torner, James ;

Guermazi, Ali ;

Roemer, Frank ;

McCulloch, Charles ;

Felson, David T. .

ARTHRITIS AND RHEUMATISM, 2011, 63 (03) :691-699

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