Advances and applications of induced pluripotent stem cells

被引：0
作者：
Pietronave, Stefano [1 ]
Prat, Maria [1 ,2 ]
机构：
[1] Univ Piemonte Orientale, Dept Hlth Sci, Histol Lab, I-28100 Novara, Italy
[2] Ctr Biotecnol Ric Med Applicata BRMA, I-28100 Novara, Italy
来源：
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 2012年 / 90卷 / 03期
关键词：
iPS; retrovirus; regenerative medicine; drug discovery; HUMAN FIBROBLASTS; EPIGENETIC MEMORY; OPEN CHROMATIN; SOMATIC-CELLS; BLOOD-CELLS; GENERATION; MOUSE; EFFICIENT; EXPRESSION; INDUCTION;
D O I：
10.1139/Y11-125
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Direct reprogramming of somatic cells into pluripotent cells is an emerging technology for creating patient-specific cells, and potentially opens new scenarios in medical and pharmacological fields. From the discovery of Shinya Yamanaka, who first obtained pluripotent cells from fibroblasts by retrovirus-derived ectopic expression of defined embryonic transcription factors, new methods have been developed to generate safe induced pluripotent stem (iPS) cells without genomic manipulations. This review will focus on the recent advances in iPS technology and their application in pharmacology and medicine.
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页码：317 / 325
页数：9
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