Assessment of circulating tumor DNA in pediatric solid tumors: The promise of liquid biopsies

被引：45

作者：

Abbou, Samuel D. ^{[1
,2
]}

Shulman, David S. ^{[1
]}

DuBois, Steven G. ^{[1
]}

Crompton, Brian D. ^{[1
,3
]}

机构：

[1] Dana Farber Boston Childrens Canc & Blood Disorde, 450 Brookline Ave, Boston, MA 02215 USA

[2] Gustave Roussy, Dept Oncol Children & Adolescents, Villejuif, France

[3] Broad Inst, Cambridge, MA USA

来源：

PEDIATRIC BLOOD & CANCER | 2019年 / 66卷 / 05期

关键词：

circulating tumor DNA; pediatric cancer; next-generation sequencing; digital PCR; liquid biopsy; CELL-FREE DNA; COLORECTAL-CANCER PATIENTS; FACTOR RECEPTOR MUTATIONS; DIGITAL PCR; COPY NUMBER; SERUM DNA; GENERAL-ANESTHESIA; MYCN AMPLIFICATION; RESIDUAL DISEASE; PLASMA DNA;

D O I：

10.1002/pbc.27595

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Circulating tumor DNA can be detected in the blood and body fluids of patients using ultrasensitive technologies, which have the potential to improve cancer diagnosis, risk stratification, noninvasive tumor profiling, and tracking of treatment response and disease recurrence. As we begin to apply "liquid biopsy" strategies in children with cancer, it is important to tailor our efforts to the unique genomic features of these tumors and address the technical and logistical challenges of integrating biomarker testing. This article reviews the literature demonstrating the feasibility of applying liquid biopsy to pediatric solid malignancies and suggests new directions for future studies.

引用

页数：12

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