Protein Structure Facilitates High-Resolution Immunological Mapping

被引：0

作者：

Zuverink, Madison ^{[1
]}

Barbieri, Joseph T. ^{[1
]}

机构：

[1] Med Coll Wisconsin, Microbiol & Immunol, Milwaukee, WI 53226 USA

来源：

CLINICAL AND VACCINE IMMUNOLOGY | 2017年 / 24卷 / 12期

关键词：

botulinum toxin; RTA; RVEc; RiVax; antibodies; mass spectrometry; ricin; BOTULINUM NEUROTOXIN SEROTYPE; INTERCHAIN DISULFIDE BOND; ANTIBODY-BINDING REGIONS; B-CELL EPITOPES; RICIN-A-CHAIN; H-N-DOMAIN; ANTITOXIN ANTIBODIES; TOXIN NEUTRALIZATION; SUBUNIT VACCINE; TETANUS;

D O I：

10.1128/CVI.00275-17

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Select agents (SA) pose unique challenges for licensing vaccines and therapies. In the case of toxin-mediated diseases, HHS assigns guidelines for SA use, oversees vaccine and therapy development, and approves animal models and approaches to identify mechanisms for toxin neutralization. In this commentary, we discuss next-generation vaccines and therapies against ricin toxin and botulinum toxin, which are regulated SA toxins that utilize structure-based approaches for countermeasures to guide rapid response to future biothreats.

引用

页数：7

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