New Heterocyclic Compounds from 1,2,4-triazoles and 1,3,4-Oxadiazoles Class Containing 5H-dibenzo[a,d] [7] Annulene Moiety

被引：0

作者：

Socea, Laura Ileana ^{[1
]}

Barbuceanu, Stefania Felicia ^{[1
]}

Draghici, Constantin ^{[2
]}

Nitulescu, George Mihai ^{[1
]}

Saramet, Gabriel ^{[1
]}

Socea, Bogdan ^{[3
]}

Apostol, Theodora Venera ^{[1
]}

机构：

[1] Univ Med & Pharm Carol Davila, Fac Pharm, 6 Traian Vuia Str, Bucharest 020956, Romania

[2] Romanian Acad, Organ Chem Ctr Costin D Nenitescu, 202B Splaiul Independenthei, Bucharest 060023, Romania

[3] Univ Med & Pharm Carol Davila, Fac Gen Med, St Pantelimon Emergency Hosp, 340-342 Soseaua Pantelimon Str, Bucharest 021623, Romania

来源：

REVISTA DE CHIMIE | 2017年 / 68卷 / 12期

关键词：

acylhydrazinecarbothioamide; 1,2,4-triazol-3-thiole; 2-amino-1,3,4-oxadiazole; dibenzo[a; d] [7] annulene; ANTIINFLAMMATORY ACTIVITY; DERIVATIVES; 1,3,4-THIADIAZOLE; ANTICONVULSANT; ANTIBACTERIAL; ITRACONAZOLE; ANTIFUNGAL; DESIGN;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this paper we present the synthesis of the new heterocyclic compounds with 5H-dibenzo[a,d][7] annulene moiety obtained by cyclization of 2-acylhydrazinecarbothioamides (2a,b). The acylhydrazinecarbothioamides were obtained by treating 2-(5H-dibenzo[a, d][7] annulen-5-yl) acetohydrazide (1) with 2,5-difluorophenyl or 3-bromophenyl isothiocyanates. 2-Amino-1,3,4-oxadiazoles (3a,b) were synthesized by cyclization of 2-acylhydrazinecarbothioamides in the presence of mercury oxide. The new 1,2,4-triazole-3-thioles (4a,b) were synthesized by cyclization, in alkaline media, of the corresponding acylhydrazinecarbothioamide. The structures of the new compounds synthesized were investigated by H-1-NMR, C-13-NMR, IR and elemental analysis.

引用

页码：2761 / 2764

页数：4

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