Comparative effects of indomethacin and nabumetone on urine and electrolyte output in conscious rats

被引:2
作者
Long, IB [1 ]
Singh, HJ [1 ]
Rao, GJ [1 ]
机构
[1] Univ Sains Malaysia, Sch Med Sci, Dept Physiol, Kelantan 16150, Malaysia
关键词
indomethacin; nabumetone; conscious rat; renal function;
D O I
10.1254/jphs.FPJ05008X
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The effects of indomethacin and nabumetone on urine and electrolyte excretion in conscious rats were examined. Male Sprague-Dawley rats were housed individually for a five-week duration, consisting of acclimatization, control, experimental, and recovery phases. During the experimental phase, rats were given either indomethacin (1.5 mg kg(-1) body weight(.)day(-1) in 0.5 ml saline, n = 10), nabumetone (15 mg(.)kg(-1) body weight(.)day(-1) 0.5 ml saline, n = 10), or 0.5 ml saline alone (n = 10) for a period of two weeks. Water and food intake, body weight, urine output, and electrolyte excretions were estimated. Data were analyzed using two-way ANOVA. Urine output in the indomethacin- and nabumetone-treated groups was not different from the controls, but was significantly different between the drug-treated groups (P < 0.01). Sodium, potassium, calcium, and magnesium excretions were not different between nabumetone-treated and control rats. However, sodium and potassium excretion was significantly lower in rats receiving indomethacin when compared to the control rats. Calcium and magnesium outputs, although did not differ from the controls, nevertheless decreased significantly with indomethacin (P < 0.01). It appears that indomethacin and nabumetone when given at maximum human therapeutic doses may affect urine and electrolyte output in conscious rats.
引用
收藏
页码:272 / 276
页数:5
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