Facial asymmetry in patients with hemifacial spasm before and after botulinum toxin A treatment

被引:8
作者
Xiao, Libin [1 ]
Pan, Yougui [1 ]
Zhang, Xiaolong [1 ]
Hu, Yong [1 ]
Cai, Li [2 ]
Nie, Zhiyu [1 ]
Pan, Lizhen [1 ]
Li, Bing [1 ]
He, Yijing [1 ]
Jin, Lingjing [1 ]
机构
[1] Tongji Univ, Shanghai Tongji Hosp, Dept Neurol, Sch Med, Xin Cun Rd 389, Shanghai 200065, Peoples R China
[2] Tongji Univ, Shanghai Tongji Hosp, Dept Sci Res, Sch Med, Xin Cun Rd 389, Shanghai 200065, Peoples R China
关键词
Facial asymmetry; Hemifacial spasm; Botulinum toxin A; EYEBROW ASYMMETRY; GRADING SYSTEM; DOUBLE-BLIND; BOTOX; BLEPHAROSPASM; NERVE; INJECTIONS; SYNKINESIS; PROSIGNE; THERAPY;
D O I
10.1007/s10072-016-2670-2
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Botulinum toxin A (BoNT-A) injection is one of the most widely used methods for hemifacial spasm (HFS) with high efficacy in controlling spasm. However, it is still unknown if esthetic symmetry could be desired as the spasm was controlled by BoNT-A therapy. The purpose of this study is to clarify the facial asymmetric characteristics of HFS patients and if the asymmetry could be amended by BoNT-A injection in the abnormal side. In this prospective analysis, HFS patients were enrolled, who received hemifacial BoNT-A injection and completed follow-up at weeks 2-4. Self-reported improvement and negative influence of facial asymmetry in social life were documented. Facial asymmetry was assessed by the Sunnybrook facial grading system (SFGS) and a new scale created by our clinic-the Symmetry Scale for Hemifacial Spasm (SSHS). Thirty-eight patients were eligible for analysis. Among them, 34 patients (89 %) had marked improvement in spasm after BoNT-A injection. After BoNT-A injection, SFGS showed an improvement of synkinesis (p = 0.01). And SSHS showed an amelioration of resting symmetry in lower face after treatment (p < 0.05). However, SFGS showed a deterioration of voluntary movement in lower face after treatment (p < 0.01). In addition, a deterioration of voluntary movement in upper face and lower face was found in SSHS after treatment (p < 0.01). SSHS composite score showed a deterioration after BoNT-A injection (p = 0.01). In conclusions, BoNT-A was effective in controlling spasm and synkinesis of HFS and improved resting symmetry in lower face, but facial symmetry of voluntary movement deteriorated after hemifacial BoNT-A injection.
引用
收藏
页码:1807 / 1813
页数:7
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