Kadlongilactones A and B, two novel triterpene dilactones from Kadsura longipedunculata possessing a unique skeleton

被引：45

作者：

Pu, JX

Xiao, WL

Lu, Y

Li, RT

Li, HM

Zhang, L

Huang, SX

Li, X

Zhao, OS

Zheng, QT

Sun, HD ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming, Yunnan, Peoples R China

[2] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

[3] Chinese Acad Sci, Grad Sch, Beijing 10039, Peoples R China

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 22期

关键词：

D O I：

10.1021/ol052161j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two novel triterpene dilactones with an unprecedented rearranged hexacyclic skeleton, kadlongilactones A (1) and B (2), have been isolated from the leaves and stems of Kadsura longipedunculata Finet et Gagnep (Schisandraceae). Their structures were established by comprehensive 1D and 2D NMR spectroscopic analysis, coupled with single-crystal X-ray crystallographic diffraction. Compounds 1 and 2 exerted significant inhibitory effects against human tumor K562 cells with IC50 = 1.40 and 1.71 mu g/mL, respectively.

引用

页码：5079 / 5082

页数：4

共 16 条

[1] Two new lignans, interiotherins A and B, as anti-HIV principles from Kadsura interior [J].

Chen, DF ;

Zhang, SX ;

Chen, K ;

Zhou, BN ;

Wang, P ;

Cosentino, LM ;

Lee, KH .

JOURNAL OF NATURAL PRODUCTS, 1996, 59 (11) :1066-1068

[2] Novel anti-HIV lancilactone C and related triterpenes from Kadsura lancilimba [J].

Chen, DF ;

Zhang, SX ;

Wang, HK ;

Zhang, SY ;

Sun, QZ ;

Cosentino, LM ;

Lee, KH .

JOURNAL OF NATURAL PRODUCTS, 1999, 62 (01) :94-97

[3]

Kuo YH, 1999, CHEM PHARM BULL, V47, P1047, DOI 10.1248/cpb.47.1047

[4] Four new C19 homolignans, schiarisanrins A, B, and D and cytotoxic schiarisanrin C, from Schizandra arisanensis [J].

Kuo, YH ;

Kuo, LMY ;

Chen, CF .

JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (10) :3242-3245

[5] Structure characterization and possible bioggenesis of three new families of nortriterpenoids: Schisanartane, schiartane, and 18-norschiartane [J].

Li, RT ;

Xiao, WL ;

Shen, YH ;

Zhao, QS ;

Sun, HD .

CHEMISTRY-A EUROPEAN JOURNAL, 2005, 11 (10) :2989-2996

[6] Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha [J].

Li, RT ;

Han, QB ;

Zheng, YT ;

Wang, RR ;

Yang, LM ;

Lu, Y ;

Sang, SQ ;

Zheng, QT ;

Zhao, QS ;

Sun, HD .

CHEMICAL COMMUNICATIONS, 2005, (23) :2936-2938

[7] Four novel nortriterpenoids isolated from Schisandra henryi var. yunnanensis [J].

Li, RT ;

Shen, YH ;

Xiang, W ;

Sun, H .

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2004, 2004 (04) :807-811

[8] Lancifodilactones B-E, new nortriterpenes from Schisandra lancifolia [J].

Li, RT ;

Xiang, W ;

Li, SH ;

Lin, ZW ;

Sun, HD .

JOURNAL OF NATURAL PRODUCTS, 2004, 67 (01) :94-97

[9] Lancifodilactone A, a novel bisnortriterpenoid from Schisandra lancifolia [J].

Li, RT ;

Li, SH ;

Zhao, QS ;

Lin, ZW ;

Sun, HD ;

Lu, Y ;

Wang, C ;

Zheng, QT .

TETRAHEDRON LETTERS, 2003, 44 (17) :3531-3534

[10] Micrandilactone A:: A novel triterpene from Schisandra micrantha [J].

Li, RT ;

Zhao, QS ;

Li, SH ;

Han, QB ;

Sun, HD ;

Lu, Y ;

Zhang, LL ;

Zheng, QT .

ORGANIC LETTERS, 2003, 5 (07) :1023-1026

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