Synthesis and Evaluation of Biological Activities of a Series of (6-substitutedbenzothiazol-2-yl)acrylamides

被引：1

作者：

Nguyen-Hai Nam ^{[1
]}

Phan Thi Phuong Dung ^{[1
]}

Doan Thanh Hieu ^{[1
]}

Le Hoang ^{[1
]}

Tran Thi Hien ^{[1
,2
]}

Tran The Cuong ^{[1
]}

Phan Dinh Chau ^{[3
]}

机构：

[1] Hanoi Univ Pharm, Dept Pharmaceut Chem, Hanoi, Vietnam

[2] Chosun Univ, Coll Pharm, Kwangju 501709, South Korea

[3] Hanoi Univ Technol, Dept Pharmaceut Technol, Hanoi, Vietnam

来源：

MEDICINAL CHEMISTRY | 2011年 / 7卷 / 06期

关键词：

Benzothiazole; cytotoxicity; synthesis; acrylamides; CANCER CELL-LINES; IN-VITRO; ANTITUMOR BENZOTHIAZOLES; DERIVATIVES; VIVO; ANTIFUNGAL; 2-(4-AMINOPHENYL)BENZOTHIAZOLES; POTENT; AGENTS; PLANTS;

D O I：

10.2174/157340611797928280

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of simple (6-substitutedbenzothiazol-2-yl)acrylamides was synthesized and evaluated for cytotoxicity and antimicrobial effects. All six compounds displayed very significant cytotoxicity against four cancer cell lines tested including A549 (a human lung cancer cell line), Hela (a human ovarian cancer cell line), MCF7 (a human breast cancer cell line), and even MCF7-ADR (adriamycin-resistant human breast cancer cell line), with IC50 values in microgram/ml range and as low as 0.66 mu g/ml. The synthesized compounds also exhibited some antifungal effects against Apergillus niger.

引用

页码：727 / 731

页数：5

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